The C. elegans unc-18 gene encodes a protein expressed in motor neurons

Keiko Gengyo-Ando, Yasuko Kamiya, Ayanori Yamakawa, Ken ichi Kodaira, Kiyoji Nishiwaki, Johji Miwa, Isao Hori, Ryuji Hosono

Research output: Contribution to journalArticlepeer-review

97 Citations (Scopus)


The C. elegans unc-18 gene is required to maintain normal acetylcholine levels. We determined the complete structure of an unc-18 cDNA that encodes a protein of 591 highly charged and hydrophilic amino acids. The protein shows sequence similarity with elements of the secretory pathway in the yeast S. cerevisiae. Antibodies raised against a portion of the unc-18-encoded protein (UNC-18) detected a 68 kd soluble antigen on immunoblots and intensely stained all ventral cord motor neurons in situ. These findings suggest that UNC-18 participates in the axonal transport system and influences the acetylcholine flow in motor neurons.

Original languageEnglish
Pages (from-to)703-711
Number of pages9
Issue number4
Publication statusPublished - 1993 Oct


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