Abstract
Cyclins and cyclin-dependent kinases (CDKs) localize to the centrosome, but their significance in the cell cycle is unclear. Recently, Roberts et al. revealed that centrosomal cyclin B-CDK is required for mitotic entry and phosphorylation of substrates. This suggests that the centrosome acts as a signaling hub controlling the cell cycle.
Original language | English |
---|---|
Pages (from-to) | 437-439 |
Number of pages | 3 |
Journal | Trends in Cell Biology |
Volume | 34 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2024 Jun |
Keywords
- cell cycle
- centrosome
- cyclin
- cyclin-dependent kinase
- spindle pole body