The centrosome: a critical hub for cell cycle regulation

Research output: Contribution to journalShort surveypeer-review

Abstract

Cyclins and cyclin-dependent kinases (CDKs) localize to the centrosome, but their significance in the cell cycle is unclear. Recently, Roberts et al. revealed that centrosomal cyclin B-CDK is required for mitotic entry and phosphorylation of substrates. This suggests that the centrosome acts as a signaling hub controlling the cell cycle.

Original languageEnglish
Pages (from-to)437-439
Number of pages3
JournalTrends in Cell Biology
Volume34
Issue number6
DOIs
Publication statusPublished - 2024 Jun

Keywords

  • cell cycle
  • centrosome
  • cyclin
  • cyclin-dependent kinase
  • spindle pole body

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