The CFTA method: A reliable procedure for the determination of the absolute configuration of chiral primary amines by 1H NMR spectroscopic analysis

Yoshio Takeuchi; Masaru Segawa; Hidehito Fujisawa; Kenji Omata; Siegfried N. Lodwig; Clifford J. Unkefer

doi:10.1002/anie.200600157

The CFTA method: A reliable procedure for the determination of the absolute configuration of chiral primary amines by ¹H NMR spectroscopic analysis

Yoshio Takeuchi, Masaru Segawa, Hidehito Fujisawa, Kenji Omata, Siegfried N. Lodwig, Clifford J. Unkefer

Division of Developmental Research in Education Programs

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Surprisingly stable anti-periplanar conformers of CFTA amides form the basis of a new and very reliable method for determining the absolute configuration of chiral primary amines by ¹H NMR spectroscopy (see picture). CFTA = α-cyano-α-fluoro-p-tolylacetic acid. (Chemical Equation Presented).

Original language	English
Pages (from-to)	4617-4619
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	28
DOIs	https://doi.org/10.1002/anie.200600157
Publication status	Published - 2006 Jul 10

Keywords

CFTA diastereomers
Configuration determination
NMR spectroscopy
Reactivity

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.200600157

Cite this

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abstract = "Surprisingly stable anti-periplanar conformers of CFTA amides form the basis of a new and very reliable method for determining the absolute configuration of chiral primary amines by 1H NMR spectroscopy (see picture). CFTA = α-cyano-α-fluoro-p-tolylacetic acid. (Chemical Equation Presented).",

keywords = "CFTA diastereomers, Configuration determination, NMR spectroscopy, Reactivity",

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AU - Omata, Kenji

AU - Lodwig, Siegfried N.

AU - Unkefer, Clifford J.

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KW - CFTA diastereomers

KW - Configuration determination

KW - NMR spectroscopy

KW - Reactivity

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