The Combination Effect of Antifungal Agents: A Clinical View

Shigefumi Maesaki, Shigeru Kohno, Ken ichi Tanaka, Kotaro Mitsutake, Takashige Miyazaki, Haruko Miyazaki, Tetsuhiro Noda, Kazunori Tomono, Mitsuo Kaku, Hironobu Koga, Kohei Hara

Research output: Contribution to journalArticlepeer-review


The in vitro and in vivo combination effect of antifungal agents was investigated. The combination of amphotericin B (AMPH) plus fluconazole (FLCZ) had a synergistic effect against Candida spp. The combination of flucytosine (5-FC) plus FLCZ had a synergistic effect against Cryptococcus neoformans isolated clinically, and the combination of AMPH plus miconazole (MCZ) was synergistic against Aspergillus fumigatus. Treatment of FLCZ plus 5-FC was shown efficacious in three cases of pulmonary cryptococcosis. Twenty cases of deep-seated mycosis were treated by the combination of MCZ plus 5-FC: seven cases showed improvement, in six cases fungi were eradicated, and side effects occurred in ten cases.

Original languageEnglish
Pages (from-to)365-368
Number of pages4
JournalNippon Ishinkin Gakkai Zasshi
Issue number4
Publication statusPublished - 1994
Externally publishedYes


  • antifungal agents
  • combination therapy
  • deep seated mycosis

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases


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