The Combination Effect of Antifungal Agents: A Clinical View

Shigefumi Maesaki; Shigeru Kohno; Ken ichi Tanaka; Kotaro Mitsutake; Takashige Miyazaki; Haruko Miyazaki; Tetsuhiro Noda; Kazunori Tomono; Mitsuo Kaku; Hironobu Koga; Kohei Hara

doi:10.3314/jjmm.35.365

The Combination Effect of Antifungal Agents: A Clinical View

Shigefumi Maesaki, Shigeru Kohno, Ken ichi Tanaka, Kotaro Mitsutake, Takashige Miyazaki, Haruko Miyazaki, Tetsuhiro Noda, Kazunori Tomono, Mitsuo Kaku, Hironobu Koga, Kohei Hara

Research output: Contribution to journal › Article › peer-review

Abstract

The in vitro and in vivo combination effect of antifungal agents was investigated. The combination of amphotericin B (AMPH) plus fluconazole (FLCZ) had a synergistic effect against Candida spp. The combination of flucytosine (5-FC) plus FLCZ had a synergistic effect against Cryptococcus neoformans isolated clinically, and the combination of AMPH plus miconazole (MCZ) was synergistic against Aspergillus fumigatus. Treatment of FLCZ plus 5-FC was shown efficacious in three cases of pulmonary cryptococcosis. Twenty cases of deep-seated mycosis were treated by the combination of MCZ plus 5-FC: seven cases showed improvement, in six cases fungi were eradicated, and side effects occurred in ten cases.

Original language	English
Pages (from-to)	365-368
Number of pages	4
Journal	Nippon Ishinkin Gakkai Zasshi
Volume	35
Issue number	4
DOIs	https://doi.org/10.3314/jjmm.35.365
Publication status	Published - 1994
Externally published	Yes

Keywords

antifungal agents
combination therapy
deep seated mycosis

ASJC Scopus subject areas

Microbiology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3314/jjmm.35.365

Cite this

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title = "The Combination Effect of Antifungal Agents: A Clinical View",

abstract = "The in vitro and in vivo combination effect of antifungal agents was investigated. The combination of amphotericin B (AMPH) plus fluconazole (FLCZ) had a synergistic effect against Candida spp. The combination of flucytosine (5-FC) plus FLCZ had a synergistic effect against Cryptococcus neoformans isolated clinically, and the combination of AMPH plus miconazole (MCZ) was synergistic against Aspergillus fumigatus. Treatment of FLCZ plus 5-FC was shown efficacious in three cases of pulmonary cryptococcosis. Twenty cases of deep-seated mycosis were treated by the combination of MCZ plus 5-FC: seven cases showed improvement, in six cases fungi were eradicated, and side effects occurred in ten cases.",

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doi = "10.3314/jjmm.35.365",

language = "English",

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T1 - The Combination Effect of Antifungal Agents

T2 - A Clinical View

AU - Maesaki, Shigefumi

AU - Kohno, Shigeru

AU - Tanaka, Ken ichi

AU - Mitsutake, Kotaro

AU - Miyazaki, Takashige

AU - Miyazaki, Haruko

AU - Noda, Tetsuhiro

AU - Tomono, Kazunori

AU - Kaku, Mitsuo

AU - Koga, Hironobu

AU - Hara, Kohei

PY - 1994

Y1 - 1994

N2 - The in vitro and in vivo combination effect of antifungal agents was investigated. The combination of amphotericin B (AMPH) plus fluconazole (FLCZ) had a synergistic effect against Candida spp. The combination of flucytosine (5-FC) plus FLCZ had a synergistic effect against Cryptococcus neoformans isolated clinically, and the combination of AMPH plus miconazole (MCZ) was synergistic against Aspergillus fumigatus. Treatment of FLCZ plus 5-FC was shown efficacious in three cases of pulmonary cryptococcosis. Twenty cases of deep-seated mycosis were treated by the combination of MCZ plus 5-FC: seven cases showed improvement, in six cases fungi were eradicated, and side effects occurred in ten cases.

AB - The in vitro and in vivo combination effect of antifungal agents was investigated. The combination of amphotericin B (AMPH) plus fluconazole (FLCZ) had a synergistic effect against Candida spp. The combination of flucytosine (5-FC) plus FLCZ had a synergistic effect against Cryptococcus neoformans isolated clinically, and the combination of AMPH plus miconazole (MCZ) was synergistic against Aspergillus fumigatus. Treatment of FLCZ plus 5-FC was shown efficacious in three cases of pulmonary cryptococcosis. Twenty cases of deep-seated mycosis were treated by the combination of MCZ plus 5-FC: seven cases showed improvement, in six cases fungi were eradicated, and side effects occurred in ten cases.

KW - antifungal agents

KW - combination therapy

KW - deep seated mycosis

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DO - 10.3314/jjmm.35.365

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JO - Japanese Journal of Medical Mycology

JF - Japanese Journal of Medical Mycology

IS - 4

ER -

The Combination Effect of Antifungal Agents: A Clinical View

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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