TY - JOUR
T1 - The combination of intralymphatic chemotherapy with ultrasound and nano-/microbubbles is efficient in the treatment of experimental tumors in mouse lymph nodes
AU - Sato, Takuma
AU - Mori, Shiro
AU - Arai, Yoichi
AU - Kodama, Tetsuya
N1 - Funding Information:
The authors thank M. Nose and M. Ono for helpful discussion, N. Sax for technical assistance and the Biomedical Research Core of Tohoku University Graduate School of Medicine for technical support. This study was supported by a Grant-in-Aid for Challenging Exploratory Research (24659884) awarded to S. Mori, and a Grant-in-Aid for Scientific Research (B) (23300183) and a Grant-in-Aid for Challenging Exploratory Research (24650286) awarded to T. Kodama.
PY - 2014/6
Y1 - 2014/6
N2 - Intravenous chemotherapy is a therapeutic option for the treatment of lymph node metastasis, but the drugs often have difficulty accessing the lymphatic system. The aim of this study was to determine whether the combination of intralymphatic chemotherapy with ultrasound and nano-/microbubbles is active against tumors in mouse lymph nodes. Intralymphatic chemotherapy in mice with lymph nodes containing tumors was found to have a marked anti-tumor effect, compared with intravenous administration, and the addition of ultrasound combined with nano-/microbubbles enhanced the effect of the anti-cancer drug, but only when the drug was administered intralymphatically. Furthermore, decreases in the volumes and blood vessel densities of tumor-bearing lymph nodes are reliable measures of therapeutic effect, confirmed by histopathological evaluation. The main conclusion is that combining ultrasound with nano-/microbubbles and intralymphatic chemotherapy improves drug delivery to the lymphatic system and has a more potent anti-tumor effect.
AB - Intravenous chemotherapy is a therapeutic option for the treatment of lymph node metastasis, but the drugs often have difficulty accessing the lymphatic system. The aim of this study was to determine whether the combination of intralymphatic chemotherapy with ultrasound and nano-/microbubbles is active against tumors in mouse lymph nodes. Intralymphatic chemotherapy in mice with lymph nodes containing tumors was found to have a marked anti-tumor effect, compared with intravenous administration, and the addition of ultrasound combined with nano-/microbubbles enhanced the effect of the anti-cancer drug, but only when the drug was administered intralymphatically. Furthermore, decreases in the volumes and blood vessel densities of tumor-bearing lymph nodes are reliable measures of therapeutic effect, confirmed by histopathological evaluation. The main conclusion is that combining ultrasound with nano-/microbubbles and intralymphatic chemotherapy improves drug delivery to the lymphatic system and has a more potent anti-tumor effect.
KW - Intralymphatic chemotherapy
KW - Lymph node metastasis
KW - Sonoporation
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=84899933767&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899933767&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2013.12.012
DO - 10.1016/j.ultrasmedbio.2013.12.012
M3 - Article
C2 - 24656719
AN - SCOPUS:84899933767
SN - 0301-5629
VL - 40
SP - 1237
EP - 1249
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 6
ER -
