The Combination Therapy with Bromocriptine and Cyproheptadine in Patients with Acromegaly

Kunihiko Hanew, Akira Sugawara, Yasuyuki Shimizu, Shuichi Sato, Atsushi Sasaki, Kaoru Yoshinaga, Satoru Tazawa, Kiyoshi Ishii, Tsuyoshi Saitoh, Shunichi Saso

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


The therapeutic efficacy of the combination of cyproheptadine and bromocriptine was studied in 15 patients with active acromegaly showing incomplete GH suppression in response to bromocriptine therapy alone. The mean basal plasma GH was 31.3±5.5 µg/L, and it decreased to 19.0±3.9 µg/L during the single bromocriptine therapy (10 to 20 mg for 2 to 21 months). When cyproheptadine (12 to 16 mg for 8 to 52 months) was added to bromocriptine therapy, plasma GH decreased further (9.4±3.0 µg/L: vs pretreatment, P< 0.001; vs bromcriptine treatment, P<0.005), and GH normalization was obtained in 8 patients. The plasma somatomedin-C levels in these 8 patients (0.3-1.8 U/ml) were within the normal range during the combination therapy. Plasma GH responses to TRH or GHRH were markedly suppressed in 6 patients during the combination therapy compared to pretreatment or during bromocriptine treatment. In addition, a clear reduction in the tumor size was observed in 4 of 7 previously untreated patients during the combination therapy. In conclusion, cyproheptadine has therapeutic efficacy in acromegalic patients who showed incomplete GH suppression in response to treatment with bromocriptine alone. Following the cyproheptadine and bromocriptine combination therapy tumor shrinkage was observed in some patients.

Original languageEnglish
Pages (from-to)429-438
Number of pages10
JournalEndocrinologia Japonica
Issue number3
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Endocrinology
  • Engineering(all)


Dive into the research topics of 'The Combination Therapy with Bromocriptine and Cyproheptadine in Patients with Acromegaly'. Together they form a unique fingerprint.

Cite this