The complex relationship of gene duplication and essentiality

Takashi Makino, Karsten Hokamp, Aoife McLysaght

Research output: Contribution to journalShort surveypeer-review

71 Citations (Scopus)


In yeast and worm, duplicate genes overlap in function so that deleting one of a pair from the genome is less likely to be lethal than deleting a singleton gene. By contrast, previous analyses showed that mouse duplicate genes were as essential as singletons. We show that the relationship between gene duplication and essentiality is complex in multicellular organisms, with developmental genes and genes that were duplicated by whole genome duplication being more essential than other duplicated genes.

Original languageEnglish
Pages (from-to)152-155
Number of pages4
JournalTrends in Genetics
Issue number4
Publication statusPublished - 2009 Apr


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