The conformational features of palytoxin in aqueous solution

Toshiyasu Inuzuka, Daisuke Uemura, Hirokazu Arimoto

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Conformational features of palytoxin and acetylated palytoxin were investigated by detailed analyses of NOESY spectra. The conformational differences between palytoxin and acetylated palytoxin may account for the difference in the assembly state of palytoxin, which exists as an associated dimer, and the acetylated derivative, which exists as a monomer in aqueous solution. Two palytoxin units in the dimer may come in contact with each other at the hydrophobic region (C21-40) and the region around two conjugated double bonds (C60-84). The amino group of palytoxin is important for biological activities via Na/K ATPase, but it was not found to be involved in the contact faces of the two palytoxin units. This information should aid in revealing how palytoxin interacts with Na/K ATPase.

Original languageEnglish
Pages (from-to)7718-7723
Number of pages6
Issue number33
Publication statusPublished - 2008 Aug 11


  • H NMR
  • Dimer
  • Na/K ATPase
  • Palytoxin


Dive into the research topics of 'The conformational features of palytoxin in aqueous solution'. Together they form a unique fingerprint.

Cite this