TY - JOUR
T1 - The critical region for Behcet disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA- B, by association analysis using refined microsatellite mapping
AU - Ota, Masao
AU - Mizuki, Nobuhisa
AU - Katsuyama, Yoshihiko
AU - Tamiya, Gen
AU - Shiina, Takashi
AU - Oka, Akira
AU - Ando, Hitoshi
AU - Kimura, Minoru
AU - Goto, Kaori
AU - Ohno, Shigeaki
AU - Inoko, Hidetoshi
N1 - Funding Information:
This work was supported by a grant from the Ministry of Health and Welfare of Japan.
PY - 1999
Y1 - 1999
N2 - The HLA-B51 allele is known to be associated with Behcet disease. Recently, we found a higher risk for Behcet disease in the MICA gene, 46 kb centromeric of HLA-B, by investigation of GCT repetitive polymorphism within exon 5 of MICA. The pathogenic gene causing Behcet disease, however, has remained uncertain. Here, eight polymorphic microsatellite markers, distributed over a 900-kb region surrounding the HLA-B locus, were subjected to association analysis for Behcet disease. Statistical studies of associated alleles detected on each microsatellite locus showed that the pathogenic gene for Behcet disease is most likely found within a 46-kb segment between the MICA and HLA-B genes. The results of this mapping study, and the results of an earlier study of ours, suggest that MICA is a strong candidate gene for the development of Behcet disease.
AB - The HLA-B51 allele is known to be associated with Behcet disease. Recently, we found a higher risk for Behcet disease in the MICA gene, 46 kb centromeric of HLA-B, by investigation of GCT repetitive polymorphism within exon 5 of MICA. The pathogenic gene causing Behcet disease, however, has remained uncertain. Here, eight polymorphic microsatellite markers, distributed over a 900-kb region surrounding the HLA-B locus, were subjected to association analysis for Behcet disease. Statistical studies of associated alleles detected on each microsatellite locus showed that the pathogenic gene for Behcet disease is most likely found within a 46-kb segment between the MICA and HLA-B genes. The results of this mapping study, and the results of an earlier study of ours, suggest that MICA is a strong candidate gene for the development of Behcet disease.
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U2 - 10.1086/302364
DO - 10.1086/302364
M3 - Article
C2 - 10205273
AN - SCOPUS:0033237816
SN - 0002-9297
VL - 64
SP - 1406
EP - 1410
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
IS - 5
ER -
