The development of a bioengineered organ germ method

Kazuhisa Nakao, Ritsuko Morita, Yasumitsu Saji, Kentaro Ishida, Yusuke Tomita, Miho Ogawa, Masahiro Saitoh, Yasuhiro Tomooka, Takashi Tsuji

Research output: Contribution to journalArticlepeer-review

325 Citations (Scopus)


To bioengineer ectodermal organs such as teeth and whisker follicles, we developed a three-dimensional organ-germ culture method. The bioengineered tooth germ generated a structurally correct tooth, after both in vitro organ culture as well as transplantation under a tooth cavity in vivo, showing penetration of blood vessels and nerve fibers. Our method provides a substantial advance in the development of bioengineered organ replacement strategies and regenerative therapies.

Original languageEnglish
Pages (from-to)227-230
Number of pages4
JournalNature Methods
Issue number3
Publication statusPublished - 2007 Mar
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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