The development of foveolar-type gastric adenocarcinoma during maintenance therapy of vonoprazan for reflux esophagitis

Masahiro Saito; Tomoyuki Koike; Yasuaki Abe; Kenichiro Nakagawa; Takeshi Kanno; Xiaoyi Jin; Waku Hatta; Kaname Uno; Naoki Asano; Akira Imatani; Fumiyoshi Fujishima; Atsushi Masamune

doi:10.2169/INTERNALMEDICINE.5431-20

The development of foveolar-type gastric adenocarcinoma during maintenance therapy of vonoprazan for reflux esophagitis

Masahiro Saito, Tomoyuki Koike, Yasuaki Abe, Kenichiro Nakagawa, Takeshi Kanno, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Atsushi Masamune

Tohoku University

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

We herein report the first case of foveolar-type gastric adenocarcinoma that developed after the initiation of vonoprazan (VPZ). A 51-year-old man had heartburn at the first visit and reflux esophagitis endoscopically, so he started taking VPZ. An approximately 5-mm-sized reddish polyp with a raspberry-like morphology was detected at the anterior wall of the upper body of the stomach 156 weeks after starting maintenance therapy with VPZ 10 mg/day. It was diagnosed as foveolar-type gastric adenocarcinoma based on a biopsy. Another approximately 4-mm-sized foveolar-type gastric adenocarcinoma was also detected at the posterior wall of the middle body of the stomach.

Original language	English
Pages (from-to)	391-396
Number of pages	6
Journal	Internal Medicine
Volume	60
Issue number	3
DOIs	https://doi.org/10.2169/INTERNALMEDICINE.5431-20
Publication status	Published - 2021 Feb 1

Keywords

Foveolar-type gastric adenocarcinoma
Potassium-competitive acid blocker (P-CAB)
Serum gastrin
Vonoprazan (VPZ)

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10.2169/INTERNALMEDICINE.5431-20

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title = "The development of foveolar-type gastric adenocarcinoma during maintenance therapy of vonoprazan for reflux esophagitis",

abstract = "We herein report the first case of foveolar-type gastric adenocarcinoma that developed after the initiation of vonoprazan (VPZ). A 51-year-old man had heartburn at the first visit and reflux esophagitis endoscopically, so he started taking VPZ. An approximately 5-mm-sized reddish polyp with a raspberry-like morphology was detected at the anterior wall of the upper body of the stomach 156 weeks after starting maintenance therapy with VPZ 10 mg/day. It was diagnosed as foveolar-type gastric adenocarcinoma based on a biopsy. Another approximately 4-mm-sized foveolar-type gastric adenocarcinoma was also detected at the posterior wall of the middle body of the stomach.",

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AU - Saito, Masahiro

AU - Koike, Tomoyuki

AU - Abe, Yasuaki

AU - Nakagawa, Kenichiro

AU - Kanno, Takeshi

AU - Jin, Xiaoyi

AU - Hatta, Waku

AU - Uno, Kaname

AU - Asano, Naoki

AU - Imatani, Akira

AU - Fujishima, Fumiyoshi

AU - Masamune, Atsushi

PY - 2021/2/1

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N2 - We herein report the first case of foveolar-type gastric adenocarcinoma that developed after the initiation of vonoprazan (VPZ). A 51-year-old man had heartburn at the first visit and reflux esophagitis endoscopically, so he started taking VPZ. An approximately 5-mm-sized reddish polyp with a raspberry-like morphology was detected at the anterior wall of the upper body of the stomach 156 weeks after starting maintenance therapy with VPZ 10 mg/day. It was diagnosed as foveolar-type gastric adenocarcinoma based on a biopsy. Another approximately 4-mm-sized foveolar-type gastric adenocarcinoma was also detected at the posterior wall of the middle body of the stomach.

AB - We herein report the first case of foveolar-type gastric adenocarcinoma that developed after the initiation of vonoprazan (VPZ). A 51-year-old man had heartburn at the first visit and reflux esophagitis endoscopically, so he started taking VPZ. An approximately 5-mm-sized reddish polyp with a raspberry-like morphology was detected at the anterior wall of the upper body of the stomach 156 weeks after starting maintenance therapy with VPZ 10 mg/day. It was diagnosed as foveolar-type gastric adenocarcinoma based on a biopsy. Another approximately 4-mm-sized foveolar-type gastric adenocarcinoma was also detected at the posterior wall of the middle body of the stomach.

KW - Foveolar-type gastric adenocarcinoma

KW - Potassium-competitive acid blocker (P-CAB)

KW - Serum gastrin

KW - Vonoprazan (VPZ)

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The development of foveolar-type gastric adenocarcinoma during maintenance therapy of vonoprazan for reflux esophagitis

Abstract

Keywords

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