The direct and enantioselective, one-pot, three-component, cross-Mannich reaction of aldehydes

Yujiro Hayashi; Wataru Tsuboi; Itaru Ashimine; Tatsuya Urushima; Mitsuru Shoji; Ken Sakai

doi:10.1002/anie.200351813

The direct and enantioselective, one-pot, three-component, cross-Mannich reaction of aldehydes

Yujiro Hayashi, Wataru Tsuboi, Itaru Ashimine, Tatsuya Urushima, Mitsuru Shoji, Ken Sakai

SCI - Chemistry

Tokyo University of Science

Research output: Contribution to journal › Article › peer-review

311 Citations (Scopus)

Abstract

A double-crossed reaction: The use of proline as an organocatalyst enables a one-pot, direct, cross-Mannich reaction to be performed between two different aldehydes and 4-methoxyaniline in a highly syn-diastereo- and enantioselective manner (see scheme).

Original language	English
Pages (from-to)	3677-3680
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	42
Issue number	31
DOIs	https://doi.org/10.1002/anie.200351813
Publication status	Published - 2003 Aug 11

Keywords

Aldehydes
Asymmetric synthesis
Enantioselectivity
Organocatalysts
Three-component reaction

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10.1002/anie.200351813

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AU - Tsuboi, Wataru

AU - Ashimine, Itaru

AU - Urushima, Tatsuya

AU - Shoji, Mitsuru

AU - Sakai, Ken

PY - 2003/8/11

Y1 - 2003/8/11

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AB - A double-crossed reaction: The use of proline as an organocatalyst enables a one-pot, direct, cross-Mannich reaction to be performed between two different aldehydes and 4-methoxyaniline in a highly syn-diastereo- and enantioselective manner (see scheme).

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KW - Asymmetric synthesis

KW - Enantioselectivity

KW - Organocatalysts

KW - Three-component reaction

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ER -

The direct and enantioselective, one-pot, three-component, cross-Mannich reaction of aldehydes

Abstract

Keywords

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