TY - JOUR
T1 - The effect of aldosterone on adiposity - The role of glucose absorption in the small intestine
AU - Shirai, Hidekazu
AU - Sato, Emiko
AU - Sekimoto, Akiyo
AU - Uchida, Taeko
AU - Oe, Yuji
AU - Ito, Sadayoshi
AU - Sato, Hiroshi
AU - Takahashi, Nobuyuki
N1 - Funding Information:
We thank technical assistance of the staff at the Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences. This study was supported by a Grant-In-Aid from the Japan Society for the Promotion of Science.
Funding Information:
We thank technical assistance of the staff at the Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences. This study was supported by a Grant-In-Aid from the Japan Society for the Promotion of Science .
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/10/22
Y1 - 2020/10/22
N2 - We have previously demonstrated that manipulation of the renin angiotensin system (RAS) has large effects on digestive efficiency. However, the effects of aldosterone on body weight, adiposity, and glucose absorption in the intestine remains unknown. We here demonstrated that lack of aldosterone synthase (ASKO) in mice did not affect adiposity. In contrast, mice administered with aldosterone were resistant to diet-induced obesity. This is due to gastrointestinal loss of dietary glucose. As expected, ASKO mice had increased glucose absorption, whereas mice administered with aldosterone had reduced glucose absorption in the small intestine. Furthermore, the level of protein expression of sodium glucose transporter 1 (SGLT1) in the mucosa of the jejunum was higher in ASKO mice, and lower in mice administered with aldosterone than control mice. Our findings indicate that aldosterone plays an important role on SGLT-1-mediated glucose absorption in the small intestine.
AB - We have previously demonstrated that manipulation of the renin angiotensin system (RAS) has large effects on digestive efficiency. However, the effects of aldosterone on body weight, adiposity, and glucose absorption in the intestine remains unknown. We here demonstrated that lack of aldosterone synthase (ASKO) in mice did not affect adiposity. In contrast, mice administered with aldosterone were resistant to diet-induced obesity. This is due to gastrointestinal loss of dietary glucose. As expected, ASKO mice had increased glucose absorption, whereas mice administered with aldosterone had reduced glucose absorption in the small intestine. Furthermore, the level of protein expression of sodium glucose transporter 1 (SGLT1) in the mucosa of the jejunum was higher in ASKO mice, and lower in mice administered with aldosterone than control mice. Our findings indicate that aldosterone plays an important role on SGLT-1-mediated glucose absorption in the small intestine.
KW - Adiposity
KW - Aldosterone
KW - Glucose absorption
KW - Sodium glucose transporter 1
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U2 - 10.1016/j.bbrc.2020.07.119
DO - 10.1016/j.bbrc.2020.07.119
M3 - Article
C2 - 32819717
AN - SCOPUS:85089511456
SN - 0006-291X
VL - 531
SP - 628
EP - 635
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 4
ER -
