TY - JOUR
T1 - The effect of crude drugs on the angiogenic property and dynamic viscoelasticity of PEMA-based soft polymer materials
AU - Wang, Wei Qi
AU - Hong, Guang
AU - Han, Jian Min
AU - Murata, Hiroshi
AU - Sasaki, Keiichi
N1 - Funding Information:
This research was supported by Grant-in-Aid (No.24792052) for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan and National Natural Science Foundation of China (Project No. 81400560).
Publisher Copyright:
© 2017, Japanese Society for Dental Materials and Devices. All rights reserved.
PY - 2017
Y1 - 2017
N2 - This study aimed to determine the effect of crude drugs on the dynamic viscoelasticity and angiogenic property of soft polymer materials, in vitro. Two kinds of polyethyl methacrylates, and crude drugs (Astragalus membranaceus Bunge [HQ] and Salvia miltiorrhiza Bunge [DS]) were used in their powdered forms. And, acetyl tributyl citrate and ethyl alcohol were used in the liquid form. The dynamic viscoelasticity of each specimen was measured after 0, 1, 3, 7, 14 and 28 days of immersion in distilled water. The CellPlayer angiogenesis PrimeKit assay was used to test angiogenesis. Significant differences in dynamic viscoelasticity were observed among the materials. Specimens containing 1 wt% HQ showed higher angiogenic activity than those containing 5 wt% and 10 wt% HQ, and DS. Our results suggest that the addition of low amounts of crude drugs to soft polymer materials may promote angiogenesis in human tissues.
AB - This study aimed to determine the effect of crude drugs on the dynamic viscoelasticity and angiogenic property of soft polymer materials, in vitro. Two kinds of polyethyl methacrylates, and crude drugs (Astragalus membranaceus Bunge [HQ] and Salvia miltiorrhiza Bunge [DS]) were used in their powdered forms. And, acetyl tributyl citrate and ethyl alcohol were used in the liquid form. The dynamic viscoelasticity of each specimen was measured after 0, 1, 3, 7, 14 and 28 days of immersion in distilled water. The CellPlayer angiogenesis PrimeKit assay was used to test angiogenesis. Significant differences in dynamic viscoelasticity were observed among the materials. Specimens containing 1 wt% HQ showed higher angiogenic activity than those containing 5 wt% and 10 wt% HQ, and DS. Our results suggest that the addition of low amounts of crude drugs to soft polymer materials may promote angiogenesis in human tissues.
KW - Angiogenesis
KW - Crude drug
KW - Dynamic viscoelasticity
KW - Soft polymer
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U2 - 10.4012/dmj.2016-387
DO - 10.4012/dmj.2016-387
M3 - Article
C2 - 28747598
AN - SCOPUS:85037539944
SN - 0287-4547
VL - 36
SP - 770
EP - 777
JO - Dental Materials Journal
JF - Dental Materials Journal
IS - 6
M1 - JST.JSTAGE/dmj/2016-387
ER -