The effect of liver hydrolysate on chronic ethanol-induced hepatic injury in normal rats

Kotaro Yamada; Kazuma Ueda; Hitoshi Shirakawa; Puspo Edi Giriwono; Satoru Honda; Hidetomo Sakurai; Michio Komai

doi:10.1248/bpb.b19-00848

The effect of liver hydrolysate on chronic ethanol-induced hepatic injury in normal rats

Kotaro Yamada, Kazuma Ueda, Hitoshi Shirakawa, Puspo Edi Giriwono, Satoru Honda, Hidetomo Sakurai, Michio Komai

AGR - Agricultural Chemistry

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The mechanism underlying the improvement in hepatic function by liver hydrolysate (LH) after ethanol-induced hepatic injury is unclear. Therefore, we investigated the effects of LH administration on chronic ethanol-induced hepatic injury in normal rats and the mechanism underlying the improvement of its symptoms by LH. LH attenuated liver damage and reduced oxidative stress after chronic ethanol-induced hepatic injury in normal rats. LH treatment reduced hepatic injury biomarkers of plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT). LH treatment also decreased levels of 8-hydroxy-deoxyguanosine (8-OHdG) as oxidative stress marker. LH may prove beneficial to prevent the liver damage of chronic ethanol, at least in part, by alleviating oxidative stress.

Original language	English
Pages (from-to)	554-557
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	43
Issue number	3
DOIs	https://doi.org/10.1248/bpb.b19-00848
Publication status	Published - 2020 Mar 1

Keywords

Chronic ethanol
Liver damage
Liver hydrolysate
Oxidative stress

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title = "The effect of liver hydrolysate on chronic ethanol-induced hepatic injury in normal rats",

abstract = "The mechanism underlying the improvement in hepatic function by liver hydrolysate (LH) after ethanol-induced hepatic injury is unclear. Therefore, we investigated the effects of LH administration on chronic ethanol-induced hepatic injury in normal rats and the mechanism underlying the improvement of its symptoms by LH. LH attenuated liver damage and reduced oxidative stress after chronic ethanol-induced hepatic injury in normal rats. LH treatment reduced hepatic injury biomarkers of plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT). LH treatment also decreased levels of 8-hydroxy-deoxyguanosine (8-OHdG) as oxidative stress marker. LH may prove beneficial to prevent the liver damage of chronic ethanol, at least in part, by alleviating oxidative stress.",

keywords = "Chronic ethanol, Liver damage, Liver hydrolysate, Oxidative stress",

author = "Kotaro Yamada and Kazuma Ueda and Hitoshi Shirakawa and Giriwono, {Puspo Edi} and Satoru Honda and Hidetomo Sakurai and Michio Komai",

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AU - Ueda, Kazuma

AU - Shirakawa, Hitoshi

AU - Giriwono, Puspo Edi

AU - Honda, Satoru

AU - Sakurai, Hidetomo

AU - Komai, Michio

N1 - Funding Information: Acknowledgments This work was partially supported by the JSPS Core-to-Core Program A (Advanced Research Networks) entitled: “Establishment of international agricultural immunology research-core for a quantum improvement in food safety.” Conflict of Interest KY, SH and HS are employees of Zeria Pharmaceutical Co., Ltd. Publisher Copyright: © 2020 The Pharmaceutical Society of Japan

PY - 2020/3/1

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N2 - The mechanism underlying the improvement in hepatic function by liver hydrolysate (LH) after ethanol-induced hepatic injury is unclear. Therefore, we investigated the effects of LH administration on chronic ethanol-induced hepatic injury in normal rats and the mechanism underlying the improvement of its symptoms by LH. LH attenuated liver damage and reduced oxidative stress after chronic ethanol-induced hepatic injury in normal rats. LH treatment reduced hepatic injury biomarkers of plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT). LH treatment also decreased levels of 8-hydroxy-deoxyguanosine (8-OHdG) as oxidative stress marker. LH may prove beneficial to prevent the liver damage of chronic ethanol, at least in part, by alleviating oxidative stress.

AB - The mechanism underlying the improvement in hepatic function by liver hydrolysate (LH) after ethanol-induced hepatic injury is unclear. Therefore, we investigated the effects of LH administration on chronic ethanol-induced hepatic injury in normal rats and the mechanism underlying the improvement of its symptoms by LH. LH attenuated liver damage and reduced oxidative stress after chronic ethanol-induced hepatic injury in normal rats. LH treatment reduced hepatic injury biomarkers of plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT). LH treatment also decreased levels of 8-hydroxy-deoxyguanosine (8-OHdG) as oxidative stress marker. LH may prove beneficial to prevent the liver damage of chronic ethanol, at least in part, by alleviating oxidative stress.

KW - Chronic ethanol

KW - Liver damage

KW - Liver hydrolysate

KW - Oxidative stress

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The effect of liver hydrolysate on chronic ethanol-induced hepatic injury in normal rats

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Keywords

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