The effect of molecular structure on the anticancer drug release rate from prodrug nanoparticles

Yoshikazu Ikuta, Yoshitaka Koseki, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

The controlled release of an anticancer agent from drug nanoparticles could be achieved by varying the linker length of dimeric compounds as prodrug. Notably, the cytotoxicity of the cancer cells was closely related to the release rate of drug compounds. This strategy will lead to the establishment of the novel delivery system using drug nanoparticles.

Original languageEnglish
Pages (from-to)12835-12838
Number of pages4
JournalChemical Communications
Volume51
Issue number64
DOIs
Publication statusPublished - 2015 Aug 18

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