The effects of prostaglandin f_2α on vascular permeability and collagen and non-collagen protein synthesis of preformed chronic carrageenin granuloma in rats

Prostaglandin F_2α (PG F_2α) was administered into the pouch fluid of 7-day-old carrageenin granuloma in rats and the effects of PG F_2α on vascular permeability and collagen and non-collagen protein synthesis of the granuloma were investigated. At a dose of 10 μg of PG F_2α, vascular permeability as measured by the leakage of radioiodinated human serum albumin into the pouch fluid was not inhibited, but at doses of 50, 100 and 250 μg of PG F_2α, vascular permeability was inhibited significantly. The incorporation of [³H]proline into collagen hydroxyproline and into non-collagen protein of carrageenin granuloma was also inhibited by local administration of PG F_2α. The mechanism of the effects of PG F_2α is discussed.