The electrochemistry and determination of Ligustrazine hydrochloride

Ziyi Sun; Xiaofeng Zheng; Tomonori Hoshi; Yoshitomo Kashiwagi; Jun Ichi Anzai; Genxi Li

doi:10.1007/s00216-004-2782-z

The electrochemistry and determination of Ligustrazine hydrochloride

Ziyi Sun, Xiaofeng Zheng, Tomonori Hoshi, Yoshitomo Kashiwagi, Jun Ichi Anzai, Genxi Li

HOSP - Clinical Research, Innovation and Education Center

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Ligustrazine is one of the active ingredients contained in Ligusticum chuanxiong Hort. (Umbelliferae), which is widely used in traditional Chinese medicine for the treatment of cardiovascular problems. In this work, the electrochemistry of Ligustrazine hydrochloride (LZC) and its determination are investigated. The detection limit is estimated to be 8.0×10^-8 M, with three linear ranges from 1.0×10^-6 to 1.0×10 ^-4 M, 1.0×10^-4 to 5.0×10^-4 M, and 6.5×10^-4 to 1.0×10^-3 M. The method has been proved to be highly sensitive, selective, and stable, and has been successfully applied to determining LZC in LZC injections.

Original language	English
Pages (from-to)	545-550
Number of pages	6
Journal	Analytical and Bioanalytical Chemistry
Volume	380
Issue number	3 SPEC.ISS.
DOIs	https://doi.org/10.1007/s00216-004-2782-z
Publication status	Published - 2004 Oct

Keywords

Cyclic voltammetry
Determination
Ligustrazine hydrochloride
Pyrolytic graphite
Square wave voltammetry

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10.1007/s00216-004-2782-z

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title = "The electrochemistry and determination of Ligustrazine hydrochloride",

abstract = "Ligustrazine is one of the active ingredients contained in Ligusticum chuanxiong Hort. (Umbelliferae), which is widely used in traditional Chinese medicine for the treatment of cardiovascular problems. In this work, the electrochemistry of Ligustrazine hydrochloride (LZC) and its determination are investigated. The detection limit is estimated to be 8.0×10-8 M, with three linear ranges from 1.0×10-6 to 1.0×10 -4 M, 1.0×10-4 to 5.0×10-4 M, and 6.5×10-4 to 1.0×10-3 M. The method has been proved to be highly sensitive, selective, and stable, and has been successfully applied to determining LZC in LZC injections.",

keywords = "Cyclic voltammetry, Determination, Ligustrazine hydrochloride, Pyrolytic graphite, Square wave voltammetry",

author = "Ziyi Sun and Xiaofeng Zheng and Tomonori Hoshi and Yoshitomo Kashiwagi and Anzai, {Jun Ichi} and Genxi Li",

note = "Funding Information: Acknowledgements We greatly appreciate the support of the Natural Science Foundation, and the Ministry of Education, China for this research.",

year = "2004",

month = oct,

doi = "10.1007/s00216-004-2782-z",

language = "English",

volume = "380",

pages = "545--550",

journal = "Analytical and Bioanalytical Chemistry",

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T1 - The electrochemistry and determination of Ligustrazine hydrochloride

AU - Sun, Ziyi

AU - Zheng, Xiaofeng

AU - Hoshi, Tomonori

AU - Kashiwagi, Yoshitomo

AU - Anzai, Jun Ichi

AU - Li, Genxi

N1 - Funding Information: Acknowledgements We greatly appreciate the support of the Natural Science Foundation, and the Ministry of Education, China for this research.

PY - 2004/10

Y1 - 2004/10

N2 - Ligustrazine is one of the active ingredients contained in Ligusticum chuanxiong Hort. (Umbelliferae), which is widely used in traditional Chinese medicine for the treatment of cardiovascular problems. In this work, the electrochemistry of Ligustrazine hydrochloride (LZC) and its determination are investigated. The detection limit is estimated to be 8.0×10-8 M, with three linear ranges from 1.0×10-6 to 1.0×10 -4 M, 1.0×10-4 to 5.0×10-4 M, and 6.5×10-4 to 1.0×10-3 M. The method has been proved to be highly sensitive, selective, and stable, and has been successfully applied to determining LZC in LZC injections.

AB - Ligustrazine is one of the active ingredients contained in Ligusticum chuanxiong Hort. (Umbelliferae), which is widely used in traditional Chinese medicine for the treatment of cardiovascular problems. In this work, the electrochemistry of Ligustrazine hydrochloride (LZC) and its determination are investigated. The detection limit is estimated to be 8.0×10-8 M, with three linear ranges from 1.0×10-6 to 1.0×10 -4 M, 1.0×10-4 to 5.0×10-4 M, and 6.5×10-4 to 1.0×10-3 M. The method has been proved to be highly sensitive, selective, and stable, and has been successfully applied to determining LZC in LZC injections.

KW - Cyclic voltammetry

KW - Determination

KW - Ligustrazine hydrochloride

KW - Pyrolytic graphite

KW - Square wave voltammetry

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U2 - 10.1007/s00216-004-2782-z

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SN - 1618-2642

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SP - 545

EP - 550

JO - Analytical and Bioanalytical Chemistry

JF - Analytical and Bioanalytical Chemistry

IS - 3 SPEC.ISS.

ER -

The electrochemistry and determination of Ligustrazine hydrochloride

Abstract

Keywords

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