The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts

Hiroyuki Matsui; Naoto Fukuno; Yoshiaki Kanda; Yusuke Kantoh; Toko Chida; Yuko Nagaura; Osamu Suzuki; Hideki Nishitoh; Kohsuke Takeda; Hidenori Ichijo; Yasuhiro Sawada; Keiichi Sasaki; Takayasu Kobayashi; Shinri Tamura

doi:10.1074/jbc.M113.536300

The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts

Hiroyuki Matsui, Naoto Fukuno, Yoshiaki Kanda, Yusuke Kantoh, Toko Chida, Yuko Nagaura, Osamu Suzuki, Hideki Nishitoh, Kohsuke Takeda, Hidenori Ichijo, Yasuhiro Sawada, Keiichi Sasaki, Takayasu Kobayashi, Shinri Tamura

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Background: Fn14 is a highly inducible member of the TNF receptor family. Results: Large-magnitude mechanical stress induced Fn14 expression via JNK in osteoblasts. Conclusion: Expression of Fn14 regulates mechanical stress-induced apoptosis in osteoblasts. Significance: This is the first elucidation of the mechanism of excessive mechanical stress-induced apoptosis mediated by Fn14.

Original language	English
Pages (from-to)	6438-6450
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	289
Issue number	10
DOIs	https://doi.org/10.1074/jbc.M113.536300
Publication status	Published - 2014 Mar 7

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Matsui, H., Fukuno, N., Kanda, Y., Kantoh, Y., Chida, T., Nagaura, Y., Suzuki, O., Nishitoh, H., Takeda, K., Ichijo, H., Sawada, Y., Sasaki, K., Kobayashi, T., & Tamura, S. (2014). The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts. Journal of Biological Chemistry, 289(10), 6438-6450. https://doi.org/10.1074/jbc.M113.536300

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abstract = "Background: Fn14 is a highly inducible member of the TNF receptor family. Results: Large-magnitude mechanical stress induced Fn14 expression via JNK in osteoblasts. Conclusion: Expression of Fn14 regulates mechanical stress-induced apoptosis in osteoblasts. Significance: This is the first elucidation of the mechanism of excessive mechanical stress-induced apoptosis mediated by Fn14.",

author = "Hiroyuki Matsui and Naoto Fukuno and Yoshiaki Kanda and Yusuke Kantoh and Toko Chida and Yuko Nagaura and Osamu Suzuki and Hideki Nishitoh and Kohsuke Takeda and Hidenori Ichijo and Yasuhiro Sawada and Keiichi Sasaki and Takayasu Kobayashi and Shinri Tamura",

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Matsui, H, Fukuno, N, Kanda, Y, Kantoh, Y, Chida, T, Nagaura, Y, Suzuki, O, Nishitoh, H, Takeda, K, Ichijo, H, Sawada, Y, Sasaki, K, Kobayashi, T & Tamura, S 2014, 'The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts', Journal of Biological Chemistry, vol. 289, no. 10, pp. 6438-6450. https://doi.org/10.1074/jbc.M113.536300

TY - JOUR

T1 - The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts

AU - Matsui, Hiroyuki

AU - Fukuno, Naoto

AU - Kanda, Yoshiaki

AU - Kantoh, Yusuke

AU - Chida, Toko

AU - Nagaura, Yuko

AU - Suzuki, Osamu

AU - Nishitoh, Hideki

AU - Takeda, Kohsuke

AU - Ichijo, Hidenori

AU - Sawada, Yasuhiro

AU - Sasaki, Keiichi

AU - Kobayashi, Takayasu

AU - Tamura, Shinri

PY - 2014/3/7

Y1 - 2014/3/7

N2 - Background: Fn14 is a highly inducible member of the TNF receptor family. Results: Large-magnitude mechanical stress induced Fn14 expression via JNK in osteoblasts. Conclusion: Expression of Fn14 regulates mechanical stress-induced apoptosis in osteoblasts. Significance: This is the first elucidation of the mechanism of excessive mechanical stress-induced apoptosis mediated by Fn14.

AB - Background: Fn14 is a highly inducible member of the TNF receptor family. Results: Large-magnitude mechanical stress induced Fn14 expression via JNK in osteoblasts. Conclusion: Expression of Fn14 regulates mechanical stress-induced apoptosis in osteoblasts. Significance: This is the first elucidation of the mechanism of excessive mechanical stress-induced apoptosis mediated by Fn14.

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SP - 6438

EP - 6450

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 10

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The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts

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