The expression of S100A4 in human pancreatic cancer is associated with invasion

Nobukazu Tsukamoto; Shinichi Egawa; Masanori Akada; Keiko Abe; Yuriko Saiki; Naoyuki Kaneko; Satoru Yokoyama; Kentaro Shima; Akihiro Yamamura; Fuyuhiko Motoi; Hisashi Abe; Hiroki Hayashi; Kazuyuki Ishida; Takuya Moriya; Takahiro Tabata; Emiko Kondo; Naomi Kanai; Zhaodi Gu; Makoto Sunamura; Michiaki Unno; Akira Horii

doi:10.1097/MPA.0b013e31828804e7

The expression of S100A4 in human pancreatic cancer is associated with invasion

Nobukazu Tsukamoto, Shinichi Egawa, Masanori Akada, Keiko Abe, Yuriko Saiki, Naoyuki Kaneko, Satoru Yokoyama, Kentaro Shima, Akihiro Yamamura, Fuyuhiko Motoi, Hisashi Abe, Hiroki Hayashi, Kazuyuki Ishida, Takuya Moriya, Takahiro Tabata, Emiko Kondo, Naomi Kanai, Zhaodi Gu, Makoto Sunamura, Michiaki UnnoAkira Horii

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

OBJECTIVES: Pancreatic cancer is one of the most lethal malignancies; its poor prognosis is strongly associated with invasion and metastasis. Expression of S100A4 has been reported to correlate with poor prognosis in various cancers. We have investigated the role of S100A4 in pancreatic cancer tumorigenesis and its clinicopathologic significance. METHODS: Protein expression of S100A4 was examined by Western blot in pancreatic cancer cell lines and a human pancreatic ductal epithelium cell line, HPDE-6. Then the expressions of S100A4, TP53, and CD133 were examined immunohistochemically in resected specimens from 83 patients with pancreatic cancer to clarify their clinicopathologic significance. Survival analyses were performed using the Kaplan-Meier method and the Mantel-Cox method. RESULTS: Forty-eight (58%) of 83 patients with pancreatic cancer positively expressed S100A4, and 50 (60%) and 29 (36%) patients positively expressed TP53 and CD133, respectively. S100A4 expression was significantly correlated with perineural invasion (P = 0.029) and invasion pattern (P = 0.001). Neither TP53 nor CD133 expression showed significant correlations with any other parameters. CONCLUSIONS: Our present results suggest that S100A4 plays an important role in the invasiveness, particularly with perineural invasion and invasion pattern, of pancreatic cancer. Development of new strategies targeting S100A4 or its downstream effectors is warranted.

Original language	English
Pages (from-to)	1027-1033
Number of pages	7
Journal	Pancreas
Volume	42
Issue number	6
DOIs	https://doi.org/10.1097/MPA.0b013e31828804e7
Publication status	Published - 2013 Aug

Keywords

clinicopathologic significance
immunohistochemistry
pancreatic cancer
S100A4
tissue microarray
TP53

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/MPA.0b013e31828804e7

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Tsukamoto, N., Egawa, S., Akada, M., Abe, K., Saiki, Y., Kaneko, N., Yokoyama, S., Shima, K., Yamamura, A., Motoi, F., Abe, H., Hayashi, H., Ishida, K., Moriya, T., Tabata, T., Kondo, E., Kanai, N., Gu, Z., Sunamura, M., ... Horii, A. (2013). The expression of S100A4 in human pancreatic cancer is associated with invasion. Pancreas, 42(6), 1027-1033. https://doi.org/10.1097/MPA.0b013e31828804e7

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title = "The expression of S100A4 in human pancreatic cancer is associated with invasion",

abstract = "OBJECTIVES: Pancreatic cancer is one of the most lethal malignancies; its poor prognosis is strongly associated with invasion and metastasis. Expression of S100A4 has been reported to correlate with poor prognosis in various cancers. We have investigated the role of S100A4 in pancreatic cancer tumorigenesis and its clinicopathologic significance. METHODS: Protein expression of S100A4 was examined by Western blot in pancreatic cancer cell lines and a human pancreatic ductal epithelium cell line, HPDE-6. Then the expressions of S100A4, TP53, and CD133 were examined immunohistochemically in resected specimens from 83 patients with pancreatic cancer to clarify their clinicopathologic significance. Survival analyses were performed using the Kaplan-Meier method and the Mantel-Cox method. RESULTS: Forty-eight (58%) of 83 patients with pancreatic cancer positively expressed S100A4, and 50 (60%) and 29 (36%) patients positively expressed TP53 and CD133, respectively. S100A4 expression was significantly correlated with perineural invasion (P = 0.029) and invasion pattern (P = 0.001). Neither TP53 nor CD133 expression showed significant correlations with any other parameters. CONCLUSIONS: Our present results suggest that S100A4 plays an important role in the invasiveness, particularly with perineural invasion and invasion pattern, of pancreatic cancer. Development of new strategies targeting S100A4 or its downstream effectors is warranted.",

keywords = "clinicopathologic significance, immunohistochemistry, pancreatic cancer, S100A4, tissue microarray, TP53",

author = "Nobukazu Tsukamoto and Shinichi Egawa and Masanori Akada and Keiko Abe and Yuriko Saiki and Naoyuki Kaneko and Satoru Yokoyama and Kentaro Shima and Akihiro Yamamura and Fuyuhiko Motoi and Hisashi Abe and Hiroki Hayashi and Kazuyuki Ishida and Takuya Moriya and Takahiro Tabata and Emiko Kondo and Naomi Kanai and Zhaodi Gu and Makoto Sunamura and Michiaki Unno and Akira Horii",

year = "2013",

month = aug,

doi = "10.1097/MPA.0b013e31828804e7",

language = "English",

volume = "42",

pages = "1027--1033",

journal = "Pancreas",

issn = "0885-3177",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "6",

}

Tsukamoto, N, Egawa, S, Akada, M, Abe, K, Saiki, Y, Kaneko, N, Yokoyama, S, Shima, K, Yamamura, A, Motoi, F, Abe, H, Hayashi, H, Ishida, K, Moriya, T, Tabata, T, Kondo, E, Kanai, N, Gu, Z, Sunamura, M, Unno, M & Horii, A 2013, 'The expression of S100A4 in human pancreatic cancer is associated with invasion', Pancreas, vol. 42, no. 6, pp. 1027-1033. https://doi.org/10.1097/MPA.0b013e31828804e7

TY - JOUR

T1 - The expression of S100A4 in human pancreatic cancer is associated with invasion

AU - Tsukamoto, Nobukazu

AU - Egawa, Shinichi

AU - Akada, Masanori

AU - Abe, Keiko

AU - Saiki, Yuriko

AU - Kaneko, Naoyuki

AU - Yokoyama, Satoru

AU - Shima, Kentaro

AU - Yamamura, Akihiro

AU - Motoi, Fuyuhiko

AU - Abe, Hisashi

AU - Hayashi, Hiroki

AU - Ishida, Kazuyuki

AU - Moriya, Takuya

AU - Tabata, Takahiro

AU - Kondo, Emiko

AU - Kanai, Naomi

AU - Gu, Zhaodi

AU - Sunamura, Makoto

AU - Unno, Michiaki

AU - Horii, Akira

PY - 2013/8

Y1 - 2013/8

N2 - OBJECTIVES: Pancreatic cancer is one of the most lethal malignancies; its poor prognosis is strongly associated with invasion and metastasis. Expression of S100A4 has been reported to correlate with poor prognosis in various cancers. We have investigated the role of S100A4 in pancreatic cancer tumorigenesis and its clinicopathologic significance. METHODS: Protein expression of S100A4 was examined by Western blot in pancreatic cancer cell lines and a human pancreatic ductal epithelium cell line, HPDE-6. Then the expressions of S100A4, TP53, and CD133 were examined immunohistochemically in resected specimens from 83 patients with pancreatic cancer to clarify their clinicopathologic significance. Survival analyses were performed using the Kaplan-Meier method and the Mantel-Cox method. RESULTS: Forty-eight (58%) of 83 patients with pancreatic cancer positively expressed S100A4, and 50 (60%) and 29 (36%) patients positively expressed TP53 and CD133, respectively. S100A4 expression was significantly correlated with perineural invasion (P = 0.029) and invasion pattern (P = 0.001). Neither TP53 nor CD133 expression showed significant correlations with any other parameters. CONCLUSIONS: Our present results suggest that S100A4 plays an important role in the invasiveness, particularly with perineural invasion and invasion pattern, of pancreatic cancer. Development of new strategies targeting S100A4 or its downstream effectors is warranted.

AB - OBJECTIVES: Pancreatic cancer is one of the most lethal malignancies; its poor prognosis is strongly associated with invasion and metastasis. Expression of S100A4 has been reported to correlate with poor prognosis in various cancers. We have investigated the role of S100A4 in pancreatic cancer tumorigenesis and its clinicopathologic significance. METHODS: Protein expression of S100A4 was examined by Western blot in pancreatic cancer cell lines and a human pancreatic ductal epithelium cell line, HPDE-6. Then the expressions of S100A4, TP53, and CD133 were examined immunohistochemically in resected specimens from 83 patients with pancreatic cancer to clarify their clinicopathologic significance. Survival analyses were performed using the Kaplan-Meier method and the Mantel-Cox method. RESULTS: Forty-eight (58%) of 83 patients with pancreatic cancer positively expressed S100A4, and 50 (60%) and 29 (36%) patients positively expressed TP53 and CD133, respectively. S100A4 expression was significantly correlated with perineural invasion (P = 0.029) and invasion pattern (P = 0.001). Neither TP53 nor CD133 expression showed significant correlations with any other parameters. CONCLUSIONS: Our present results suggest that S100A4 plays an important role in the invasiveness, particularly with perineural invasion and invasion pattern, of pancreatic cancer. Development of new strategies targeting S100A4 or its downstream effectors is warranted.

KW - clinicopathologic significance

KW - immunohistochemistry

KW - pancreatic cancer

KW - S100A4

KW - tissue microarray

KW - TP53

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U2 - 10.1097/MPA.0b013e31828804e7

DO - 10.1097/MPA.0b013e31828804e7

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C2 - 23851436

AN - SCOPUS:84880680413

SN - 0885-3177

VL - 42

SP - 1027

EP - 1033

JO - Pancreas

JF - Pancreas

IS - 6

ER -

The expression of S100A4 in human pancreatic cancer is associated with invasion

Abstract

Keywords

UN SDGs

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