The eyeless homeodomain is dispensable for eye development in Drosophila

C. Punzo, S. Kurata, W. J. Gehring

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)


Pax-6 genes, known to be essential for eye development, encode an evolutionarily conserved transcription factor with two DNA-binding domains. To corroborate the contribution of each DNA-binding domain to eye formation, we generated truncated forms of the Drosophila Pax-6 gene eyeless and tested their capacity to rescue the ey2 mutant. Surprisingly, EY deleted of the homeodomain rescued the ey2 mutant and triggered ectopic eyes morphogenesis. In contrast, EY lacking the paired domain failed to rescue the ey2 mutant, led to truncation of appendages, and repressed Distal-less when misexpressed. This result suggests distinct functions mediated differentially by the two DNA-binding domains of eyeless.

Original languageEnglish
Pages (from-to)1716-1723
Number of pages8
JournalGenes and Development
Issue number13
Publication statusPublished - 2001 Jul 1


  • Eye development
  • Eyeless
  • Homeodomain
  • Paired domain
  • Pax-6


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