The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis

Takeshi Inagaki; Satoshi Iwasaki; Yoshihiro Matsumura; Takeshi Kawamura; Toshiya Tanaka; Yohei Abe; Ayumu Yamasaki; Yuya Tsurutani; Ayano Yoshida; Yoko Chikaoka; Kanako Nakamura; Kenta Magoori; Ryo Nakaki; Timothy F. Osborne; Kiyoko Fukami; Hiroyuki Aburatani; Tatsuhiko Kodama; Juro Sakai

doi:10.1074/jbc.M114.626929

The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis

Takeshi Inagaki, Satoshi Iwasaki, Yoshihiro Matsumura, Takeshi Kawamura, Toshiya Tanaka, Yohei Abe, Ayumu Yamasaki, Yuya Tsurutani, Ayano Yoshida, Yoko Chikaoka, Kanako Nakamura, Kenta Magoori, Ryo Nakaki, Timothy F. Osborne, Kiyoko Fukami, Hiroyuki Aburatani, Tatsuhiko Kodama, Juro Sakai

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Background: Polycomb repressive complex PRC1 is an epigenetic regulator of cellular differentiation. However, its function during adipogenesis is unknown. Results: FBXL10/KDM2B recruited noncanonical PRC1 complex in F-box and LRR motifs dependent on cell cycle-related genes and Pparg genes and repressed 3T3-L1 adipogenesis. Conclusion: Noncanonical PRC1 complex containing FBXL10/KDM2B regulates adipogenesis. Significance: Our findings revealed a novel epigenetic mechanism of adipogenesis.

Original language	English
Pages (from-to)	4163-4177
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	290
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M114.626929
Publication status	Published - 2015 Feb 13
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Inagaki, T., Iwasaki, S., Matsumura, Y., Kawamura, T., Tanaka, T., Abe, Y., Yamasaki, A., Tsurutani, Y., Yoshida, A., Chikaoka, Y., Nakamura, K., Magoori, K., Nakaki, R., Osborne, T. F., Fukami, K., Aburatani, H., Kodama, T., & Sakai, J. (2015). The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis. Journal of Biological Chemistry, 290(7), 4163-4177. https://doi.org/10.1074/jbc.M114.626929

Inagaki, T, Iwasaki, S, Matsumura, Y, Kawamura, T, Tanaka, T, Abe, Y, Yamasaki, A, Tsurutani, Y, Yoshida, A, Chikaoka, Y, Nakamura, K, Magoori, K, Nakaki, R, Osborne, TF, Fukami, K, Aburatani, H, Kodama, T & Sakai, J 2015, 'The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis', Journal of Biological Chemistry, vol. 290, no. 7, pp. 4163-4177. https://doi.org/10.1074/jbc.M114.626929

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title = "The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis",

abstract = "Background: Polycomb repressive complex PRC1 is an epigenetic regulator of cellular differentiation. However, its function during adipogenesis is unknown. Results: FBXL10/KDM2B recruited noncanonical PRC1 complex in F-box and LRR motifs dependent on cell cycle-related genes and Pparg genes and repressed 3T3-L1 adipogenesis. Conclusion: Noncanonical PRC1 complex containing FBXL10/KDM2B regulates adipogenesis. Significance: Our findings revealed a novel epigenetic mechanism of adipogenesis.",

author = "Takeshi Inagaki and Satoshi Iwasaki and Yoshihiro Matsumura and Takeshi Kawamura and Toshiya Tanaka and Yohei Abe and Ayumu Yamasaki and Yuya Tsurutani and Ayano Yoshida and Yoko Chikaoka and Kanako Nakamura and Kenta Magoori and Ryo Nakaki and Osborne, {Timothy F.} and Kiyoko Fukami and Hiroyuki Aburatani and Tatsuhiko Kodama and Juro Sakai",

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doi = "10.1074/jbc.M114.626929",

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AU - Inagaki, Takeshi

AU - Iwasaki, Satoshi

AU - Matsumura, Yoshihiro

AU - Kawamura, Takeshi

AU - Tanaka, Toshiya

AU - Abe, Yohei

AU - Yamasaki, Ayumu

AU - Tsurutani, Yuya

AU - Yoshida, Ayano

AU - Chikaoka, Yoko

AU - Nakamura, Kanako

AU - Magoori, Kenta

AU - Nakaki, Ryo

AU - Osborne, Timothy F.

AU - Fukami, Kiyoko

AU - Aburatani, Hiroyuki

AU - Kodama, Tatsuhiko

AU - Sakai, Juro

PY - 2015/2/13

Y1 - 2015/2/13

N2 - Background: Polycomb repressive complex PRC1 is an epigenetic regulator of cellular differentiation. However, its function during adipogenesis is unknown. Results: FBXL10/KDM2B recruited noncanonical PRC1 complex in F-box and LRR motifs dependent on cell cycle-related genes and Pparg genes and repressed 3T3-L1 adipogenesis. Conclusion: Noncanonical PRC1 complex containing FBXL10/KDM2B regulates adipogenesis. Significance: Our findings revealed a novel epigenetic mechanism of adipogenesis.

AB - Background: Polycomb repressive complex PRC1 is an epigenetic regulator of cellular differentiation. However, its function during adipogenesis is unknown. Results: FBXL10/KDM2B recruited noncanonical PRC1 complex in F-box and LRR motifs dependent on cell cycle-related genes and Pparg genes and repressed 3T3-L1 adipogenesis. Conclusion: Noncanonical PRC1 complex containing FBXL10/KDM2B regulates adipogenesis. Significance: Our findings revealed a novel epigenetic mechanism of adipogenesis.

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The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis

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