The first nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy. Part 1: A general view of antibacterial susceptibility

Y. Niki; H. Hanaki; M. Yagisawa; S. Kohno; N. Aoki; A. Watanabe; J. Sato; R. Hattori; N. Koashi; T. Kozuki; A. Maruo; K. Morita; K. Ogasawara; Y. Takahashi; J. Watanabe; K. Takeuchi; M. Takahashi; H. Takeda; H. Ikeda; H. Kaneda; K. Niitsuma; M. Saito; S. Koshiba; M. Kaneko; S. Itabashi; M. Miki; S. Nakanowatari; Y. Honda; J. Chiba; H. Takahashi; M. Utagawa; T. Kondo; A. Kawana; H. Konosaki; Y. Aoki; N. Chonabayashi; H. Ueda; H. Sugiura; M. Ichioka; H. Goto; M. Aoshima; M. Okazaki; T. Ozawa; F. Horiuchi; T. Yoshida; H. Tsukada; S. Kobayashi; H. Yoshikawa; Y. Imai; N. Aoki; Y. Honma; K. Yoshida; M. Takaya; Y. Kurokawa; M. Kuwabara; Y. Fujiue; T. Ishimaru; N. Matsubara; Y. Kawasaki; H. Tokuyasu; K. Masui; E. Shimizu; K. Yoneda; K. Negayama; N. Ueda; M. Ishimaru; Y. Nakanishi; M. Fujita; J. Honda; J. Kadota; K. Hiramatsu; Y. Aoki; Z. Nagasawa; M. Suga; H. Muranaka; S. Kohno; K. Yanagihara; J. Fujita; M. Tateyama; K. Totsuka

doi:10.1007/s10156-008-0623-2

The first nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy. Part 1: A general view of antibacterial susceptibility

Y. Niki, H. Hanaki, M. Yagisawa, S. Kohno, N. Aoki, A. Watanabe, J. Sato, R. Hattori, N. Koashi, T. Kozuki, A. Maruo, K. Morita, K. Ogasawara, Y. Takahashi, J. Watanabe, K. Takeuchi, M. Takahashi, H. Takeda, H. Ikeda, H. KanedaK. Niitsuma, M. Saito, S. Koshiba, M. Kaneko, S. Itabashi, M. Miki, S. Nakanowatari, Y. Honda, J. Chiba, H. Takahashi, M. Utagawa, T. Kondo, A. Kawana, H. Konosaki, Y. Aoki, N. Chonabayashi, H. Ueda, H. Sugiura, M. Ichioka, H. Goto, M. Aoshima, M. Okazaki, T. Ozawa, F. Horiuchi, T. Yoshida, H. Tsukada, S. Kobayashi, H. Yoshikawa, Y. Imai, N. Aoki, Y. Honma, K. Yoshida, M. Takaya, Y. Kurokawa, M. Kuwabara, Y. Fujiue, T. Ishimaru, N. Matsubara, Y. Kawasaki, H. Tokuyasu, K. Masui, E. Shimizu, K. Yoneda, K. Negayama, N. Ueda, M. Ishimaru, Y. Nakanishi, M. Fujita, J. Honda, J. Kadota, K. Hiramatsu, Y. Aoki, Z. Nagasawa, M. Suga, H. Muranaka, S. Kohno, K. Yanagihara, J. Fujita, M. Tateyama, K. Totsuka

Research output: Contribution to journal › Article › peer-review

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Abstract

The Japanese Society of Chemotherapy (JSC) conducted the first nationwide surveillance of bacterial respiratory pathogens during the period from January to August 2006. With the cooperation of 32 medical institutions throughout Japan, a total of 924 strains belonging to seven clinically relevant bacterial species were collected from adult patients with well-diagnosed respiratory tract infections (RTIs). Antimicrobial susceptibility testing of the 887 evaluable strains (205 Staphylococcus aureus, 200 Streptococcus pneumoniae, 9 Streptococcus pyogenes, 165 Haemophilus influenzae, 91 Moraxella catarrhalis, 74 Klebsiella pneumoniae, and 143 Pseudomonas aeruginosa) to 42 antibacterial agents was conducted at the Central Laboratory of the Research Center for Anti-infective Drugs of the Kitasato Institute, according to recommendations issued by the Clinical and Laboratory Standards Institute (CLSI). The antibacterial agents employed were 25 β-lactams, three aminoglycosides, four macrolides (including one azalide and one ketolide), one lincosamide, one tetracycline, two glycopeptides, five fluoroquinolones, and one oxazolidinone. The incidence of methicillin-resistant S. aureus (MRSA) was 63.4%, and the incidences of penicillin-intermediately resistant S. pneumoniae (PISP) and penicillin-resistant S. pneumoniae (PRSP) were 35.0% and 4.0%, respectively. Among H. influenzae, 21.2% of the strains were found to be β-lactamase- nonproducing ampicillin (ABPC)-intermediately resistant (BLNAI), 29.1% to be β-lactamase-nonproducing ABPC-resistant (BLNAR), and 4.8% to be β-lactamaseproducing ABPC-resistant (BLPAR) strains. The incidence of extended-spectrum β-lactamase-producing K. pneumoniae was 2.7% (2 of 74 strains). Three (2.1%) of the 143 P. aeruginosa strains were found to be metallo-β-lactamaseproducing, including 1 (0.7%) multidrug-resistant strain. Through the nationwide surveillance, we obtained fundamental antimicrobial susceptibility data of clinically relevant bacterial pathogens in adult RTI to various antibacterial agents. These data will be a useful reference for future periodic surveillance studies, as well as for investigations to control antimicrobial-resistant pathogens.

Original language	English
Pages (from-to)	279-290
Number of pages	12
Journal	Journal of Infection and Chemotherapy
Volume	14
Issue number	4
DOIs	https://doi.org/10.1007/s10156-008-0623-2
Publication status	Published - 2008 Aug
Externally published	Yes

Keywords

Drug
Resistance
Respiratory tract infection
Surveillance
Susceptibility

ASJC Scopus subject areas

Microbiology (medical)
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10156-008-0623-2

Cite this

Niki, Y., Hanaki, H., Yagisawa, M., Kohno, S., Aoki, N., Watanabe, A., Sato, J., Hattori, R., Koashi, N., Kozuki, T., Maruo, A., Morita, K., Ogasawara, K., Takahashi, Y., Watanabe, J., Takeuchi, K., Takahashi, M., Takeda, H., Ikeda, H., ... Totsuka, K. (2008). The first nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy. Part 1: A general view of antibacterial susceptibility. Journal of Infection and Chemotherapy, 14(4), 279-290. https://doi.org/10.1007/s10156-008-0623-2

Niki, Y, Hanaki, H, Yagisawa, M, Kohno, S, Aoki, N, Watanabe, A, Sato, J, Hattori, R, Koashi, N, Kozuki, T, Maruo, A, Morita, K, Ogasawara, K, Takahashi, Y, Watanabe, J, Takeuchi, K, Takahashi, M, Takeda, H, Ikeda, H, Kaneda, H, Niitsuma, K, Saito, M, Koshiba, S, Kaneko, M, Itabashi, S, Miki, M, Nakanowatari, S, Honda, Y, Chiba, J, Takahashi, H, Utagawa, M, Kondo, T, Kawana, A, Konosaki, H, Aoki, Y, Chonabayashi, N, Ueda, H, Sugiura, H, Ichioka, M, Goto, H, Aoshima, M, Okazaki, M, Ozawa, T, Horiuchi, F, Yoshida, T, Tsukada, H, Kobayashi, S, Yoshikawa, H, Imai, Y, Aoki, N, Honma, Y, Yoshida, K, Takaya, M, Kurokawa, Y, Kuwabara, M, Fujiue, Y, Ishimaru, T, Matsubara, N, Kawasaki, Y, Tokuyasu, H, Masui, K, Shimizu, E, Yoneda, K, Negayama, K, Ueda, N, Ishimaru, M, Nakanishi, Y, Fujita, M, Honda, J, Kadota, J, Hiramatsu, K, Aoki, Y, Nagasawa, Z, Suga, M, Muranaka, H, Kohno, S, Yanagihara, K, Fujita, J, Tateyama, M & Totsuka, K 2008, 'The first nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy. Part 1: A general view of antibacterial susceptibility', Journal of Infection and Chemotherapy, vol. 14, no. 4, pp. 279-290. https://doi.org/10.1007/s10156-008-0623-2

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title = "The first nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy. Part 1: A general view of antibacterial susceptibility",

abstract = "The Japanese Society of Chemotherapy (JSC) conducted the first nationwide surveillance of bacterial respiratory pathogens during the period from January to August 2006. With the cooperation of 32 medical institutions throughout Japan, a total of 924 strains belonging to seven clinically relevant bacterial species were collected from adult patients with well-diagnosed respiratory tract infections (RTIs). Antimicrobial susceptibility testing of the 887 evaluable strains (205 Staphylococcus aureus, 200 Streptococcus pneumoniae, 9 Streptococcus pyogenes, 165 Haemophilus influenzae, 91 Moraxella catarrhalis, 74 Klebsiella pneumoniae, and 143 Pseudomonas aeruginosa) to 42 antibacterial agents was conducted at the Central Laboratory of the Research Center for Anti-infective Drugs of the Kitasato Institute, according to recommendations issued by the Clinical and Laboratory Standards Institute (CLSI). The antibacterial agents employed were 25 β-lactams, three aminoglycosides, four macrolides (including one azalide and one ketolide), one lincosamide, one tetracycline, two glycopeptides, five fluoroquinolones, and one oxazolidinone. The incidence of methicillin-resistant S. aureus (MRSA) was 63.4%, and the incidences of penicillin-intermediately resistant S. pneumoniae (PISP) and penicillin-resistant S. pneumoniae (PRSP) were 35.0% and 4.0%, respectively. Among H. influenzae, 21.2% of the strains were found to be β-lactamase- nonproducing ampicillin (ABPC)-intermediately resistant (BLNAI), 29.1% to be β-lactamase-nonproducing ABPC-resistant (BLNAR), and 4.8% to be β-lactamaseproducing ABPC-resistant (BLPAR) strains. The incidence of extended-spectrum β-lactamase-producing K. pneumoniae was 2.7% (2 of 74 strains). Three (2.1%) of the 143 P. aeruginosa strains were found to be metallo-β-lactamaseproducing, including 1 (0.7%) multidrug-resistant strain. Through the nationwide surveillance, we obtained fundamental antimicrobial susceptibility data of clinically relevant bacterial pathogens in adult RTI to various antibacterial agents. These data will be a useful reference for future periodic surveillance studies, as well as for investigations to control antimicrobial-resistant pathogens.",

keywords = "Drug, Resistance, Respiratory tract infection, Surveillance, Susceptibility",

author = "Y. Niki and H. Hanaki and M. Yagisawa and S. Kohno and N. Aoki and A. Watanabe and J. Sato and R. Hattori and N. Koashi and T. Kozuki and A. Maruo and K. Morita and K. Ogasawara and Y. Takahashi and J. Watanabe and K. Takeuchi and M. Takahashi and H. Takeda and H. Ikeda and H. Kaneda and K. Niitsuma and M. Saito and S. Koshiba and M. Kaneko and S. Itabashi and M. Miki and S. Nakanowatari and Y. Honda and J. Chiba and H. Takahashi and M. Utagawa and T. Kondo and A. Kawana and H. Konosaki and Y. Aoki and N. Chonabayashi and H. Ueda and H. Sugiura and M. Ichioka and H. Goto and M. Aoshima and M. Okazaki and T. Ozawa and F. Horiuchi and T. Yoshida and H. Tsukada and S. Kobayashi and H. Yoshikawa and Y. Imai and N. Aoki and Y. Honma and K. Yoshida and M. Takaya and Y. Kurokawa and M. Kuwabara and Y. Fujiue and T. Ishimaru and N. Matsubara and Y. Kawasaki and H. Tokuyasu and K. Masui and E. Shimizu and K. Yoneda and K. Negayama and N. Ueda and M. Ishimaru and Y. Nakanishi and M. Fujita and J. Honda and J. Kadota and K. Hiramatsu and Y. Aoki and Z. Nagasawa and M. Suga and H. Muranaka and S. Kohno and K. Yanagihara and J. Fujita and M. Tateyama and K. Totsuka",

year = "2008",

month = aug,

doi = "10.1007/s10156-008-0623-2",

language = "English",

volume = "14",

pages = "279--290",

journal = "Journal of Infection and Chemotherapy",

issn = "1341-321X",

publisher = "Elsevier BV",

number = "4",

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TY - JOUR

T1 - The first nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy. Part 1

T2 - A general view of antibacterial susceptibility

AU - Niki, Y.

AU - Hanaki, H.

AU - Yagisawa, M.

AU - Kohno, S.

AU - Aoki, N.

AU - Watanabe, A.

AU - Sato, J.

AU - Hattori, R.

AU - Koashi, N.

AU - Kozuki, T.

AU - Maruo, A.

AU - Morita, K.

AU - Ogasawara, K.

AU - Takahashi, Y.

AU - Watanabe, J.

AU - Takeuchi, K.

AU - Takahashi, M.

AU - Takeda, H.

AU - Ikeda, H.

AU - Kaneda, H.

AU - Niitsuma, K.

AU - Saito, M.

AU - Koshiba, S.

AU - Kaneko, M.

AU - Itabashi, S.

AU - Miki, M.

AU - Nakanowatari, S.

AU - Honda, Y.

AU - Chiba, J.

AU - Takahashi, H.

AU - Utagawa, M.

AU - Kondo, T.

AU - Kawana, A.

AU - Konosaki, H.

AU - Aoki, Y.

AU - Chonabayashi, N.

AU - Ueda, H.

AU - Sugiura, H.

AU - Ichioka, M.

AU - Goto, H.

AU - Aoshima, M.

AU - Okazaki, M.

AU - Ozawa, T.

AU - Horiuchi, F.

AU - Yoshida, T.

AU - Tsukada, H.

AU - Kobayashi, S.

AU - Yoshikawa, H.

AU - Imai, Y.

AU - Aoki, N.

AU - Honma, Y.

AU - Yoshida, K.

AU - Takaya, M.

AU - Kurokawa, Y.

AU - Kuwabara, M.

AU - Fujiue, Y.

AU - Ishimaru, T.

AU - Matsubara, N.

AU - Kawasaki, Y.

AU - Tokuyasu, H.

AU - Masui, K.

AU - Shimizu, E.

AU - Yoneda, K.

AU - Negayama, K.

AU - Ueda, N.

AU - Ishimaru, M.

AU - Nakanishi, Y.

AU - Fujita, M.

AU - Honda, J.

AU - Kadota, J.

AU - Hiramatsu, K.

AU - Aoki, Y.

AU - Nagasawa, Z.

AU - Suga, M.

AU - Muranaka, H.

AU - Kohno, S.

AU - Yanagihara, K.

AU - Fujita, J.

AU - Tateyama, M.

AU - Totsuka, K.

PY - 2008/8

Y1 - 2008/8

N2 - The Japanese Society of Chemotherapy (JSC) conducted the first nationwide surveillance of bacterial respiratory pathogens during the period from January to August 2006. With the cooperation of 32 medical institutions throughout Japan, a total of 924 strains belonging to seven clinically relevant bacterial species were collected from adult patients with well-diagnosed respiratory tract infections (RTIs). Antimicrobial susceptibility testing of the 887 evaluable strains (205 Staphylococcus aureus, 200 Streptococcus pneumoniae, 9 Streptococcus pyogenes, 165 Haemophilus influenzae, 91 Moraxella catarrhalis, 74 Klebsiella pneumoniae, and 143 Pseudomonas aeruginosa) to 42 antibacterial agents was conducted at the Central Laboratory of the Research Center for Anti-infective Drugs of the Kitasato Institute, according to recommendations issued by the Clinical and Laboratory Standards Institute (CLSI). The antibacterial agents employed were 25 β-lactams, three aminoglycosides, four macrolides (including one azalide and one ketolide), one lincosamide, one tetracycline, two glycopeptides, five fluoroquinolones, and one oxazolidinone. The incidence of methicillin-resistant S. aureus (MRSA) was 63.4%, and the incidences of penicillin-intermediately resistant S. pneumoniae (PISP) and penicillin-resistant S. pneumoniae (PRSP) were 35.0% and 4.0%, respectively. Among H. influenzae, 21.2% of the strains were found to be β-lactamase- nonproducing ampicillin (ABPC)-intermediately resistant (BLNAI), 29.1% to be β-lactamase-nonproducing ABPC-resistant (BLNAR), and 4.8% to be β-lactamaseproducing ABPC-resistant (BLPAR) strains. The incidence of extended-spectrum β-lactamase-producing K. pneumoniae was 2.7% (2 of 74 strains). Three (2.1%) of the 143 P. aeruginosa strains were found to be metallo-β-lactamaseproducing, including 1 (0.7%) multidrug-resistant strain. Through the nationwide surveillance, we obtained fundamental antimicrobial susceptibility data of clinically relevant bacterial pathogens in adult RTI to various antibacterial agents. These data will be a useful reference for future periodic surveillance studies, as well as for investigations to control antimicrobial-resistant pathogens.

AB - The Japanese Society of Chemotherapy (JSC) conducted the first nationwide surveillance of bacterial respiratory pathogens during the period from January to August 2006. With the cooperation of 32 medical institutions throughout Japan, a total of 924 strains belonging to seven clinically relevant bacterial species were collected from adult patients with well-diagnosed respiratory tract infections (RTIs). Antimicrobial susceptibility testing of the 887 evaluable strains (205 Staphylococcus aureus, 200 Streptococcus pneumoniae, 9 Streptococcus pyogenes, 165 Haemophilus influenzae, 91 Moraxella catarrhalis, 74 Klebsiella pneumoniae, and 143 Pseudomonas aeruginosa) to 42 antibacterial agents was conducted at the Central Laboratory of the Research Center for Anti-infective Drugs of the Kitasato Institute, according to recommendations issued by the Clinical and Laboratory Standards Institute (CLSI). The antibacterial agents employed were 25 β-lactams, three aminoglycosides, four macrolides (including one azalide and one ketolide), one lincosamide, one tetracycline, two glycopeptides, five fluoroquinolones, and one oxazolidinone. The incidence of methicillin-resistant S. aureus (MRSA) was 63.4%, and the incidences of penicillin-intermediately resistant S. pneumoniae (PISP) and penicillin-resistant S. pneumoniae (PRSP) were 35.0% and 4.0%, respectively. Among H. influenzae, 21.2% of the strains were found to be β-lactamase- nonproducing ampicillin (ABPC)-intermediately resistant (BLNAI), 29.1% to be β-lactamase-nonproducing ABPC-resistant (BLNAR), and 4.8% to be β-lactamaseproducing ABPC-resistant (BLPAR) strains. The incidence of extended-spectrum β-lactamase-producing K. pneumoniae was 2.7% (2 of 74 strains). Three (2.1%) of the 143 P. aeruginosa strains were found to be metallo-β-lactamaseproducing, including 1 (0.7%) multidrug-resistant strain. Through the nationwide surveillance, we obtained fundamental antimicrobial susceptibility data of clinically relevant bacterial pathogens in adult RTI to various antibacterial agents. These data will be a useful reference for future periodic surveillance studies, as well as for investigations to control antimicrobial-resistant pathogens.

KW - Drug

KW - Resistance

KW - Respiratory tract infection

KW - Surveillance

KW - Susceptibility

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SN - 1341-321X

VL - 14

SP - 279

EP - 290

JO - Journal of Infection and Chemotherapy

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IS - 4

ER -

The first nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy. Part 1: A general view of antibacterial susceptibility

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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