TY - JOUR
T1 - The helical flow pump with a hydrodynamic levitation impeller
AU - Abe, Yusuke
AU - Ishii, Kohei
AU - Isoyama, Takashi
AU - Saito, Itsuro
AU - Inoue, Yusuke
AU - Ono, Toshiya
AU - Nakagawa, Hidemoto
AU - Nakano, Emiko
AU - Fukazawa, Kyoko
AU - Ishihara, Kazuhiko
AU - Fukunaga, Kazuyoshi
AU - Ono, Minoru
AU - Imachi, Kou
PY - 2012/12
Y1 - 2012/12
N2 - The helical flow pump (HFP) is a novel rotary blood pump invented for developing a total artificial heart (TAH). The HFP with a hydrodynamic levitation impeller, which consists of a multi-vane impeller involving rotor magnets, stator coils at the core position, and double helical-volute pump housing, was developed. Between the stator and impeller, a hydrodynamic bearing is formed. Since the helical volutes are formed at both sides of the impeller, blood flows with a helical flow pattern inside the pump. The developed HFP showed maximum output of 19 l/min against 100 mmHg of pressure head and 11 % maximum efficiency. The profile of the H-Q (pressure head vs. flow) curve was similar to that of the undulation pump. Hydrodynamic levitation of the impeller was possible with higher than 1,000 rpm rotation speed. The normalized index of the hemolysis ratio of the HFP to centrifugal pump (BPX-80) was from 2.61 to 8.07 depending on the design of the bearing. The HFP was implanted in two goats with a left ventricular bypass method. After surgery, hemolysis occurred in both goats. The hemolysis ceased on postoperative days 14 and 9, respectively. In the first experiment, no thrombus was found in the pump after 203 days of pumping. In the second experiment, a white thrombus was found in the pump after 23 days of pumping. While further research and development are necessary, we are expecting to develop an excellent TAH with the HFP.
AB - The helical flow pump (HFP) is a novel rotary blood pump invented for developing a total artificial heart (TAH). The HFP with a hydrodynamic levitation impeller, which consists of a multi-vane impeller involving rotor magnets, stator coils at the core position, and double helical-volute pump housing, was developed. Between the stator and impeller, a hydrodynamic bearing is formed. Since the helical volutes are formed at both sides of the impeller, blood flows with a helical flow pattern inside the pump. The developed HFP showed maximum output of 19 l/min against 100 mmHg of pressure head and 11 % maximum efficiency. The profile of the H-Q (pressure head vs. flow) curve was similar to that of the undulation pump. Hydrodynamic levitation of the impeller was possible with higher than 1,000 rpm rotation speed. The normalized index of the hemolysis ratio of the HFP to centrifugal pump (BPX-80) was from 2.61 to 8.07 depending on the design of the bearing. The HFP was implanted in two goats with a left ventricular bypass method. After surgery, hemolysis occurred in both goats. The hemolysis ceased on postoperative days 14 and 9, respectively. In the first experiment, no thrombus was found in the pump after 203 days of pumping. In the second experiment, a white thrombus was found in the pump after 23 days of pumping. While further research and development are necessary, we are expecting to develop an excellent TAH with the HFP.
KW - Helical flow pump
KW - Hydrodynamic bearing
KW - Left ventricular bypass
KW - Rotary blood pump
KW - Total artificial heart
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U2 - 10.1007/s10047-012-0659-z
DO - 10.1007/s10047-012-0659-z
M3 - Article
C2 - 22926404
AN - SCOPUS:84876295871
SN - 1434-7229
VL - 15
SP - 331
EP - 340
JO - Journal of Artificial Organs
JF - Journal of Artificial Organs
IS - 4
ER -