TY - JOUR
T1 - The Katsuki-Sharpless asymmetric epoxidation of (E)-2,5-dihydroxy-2,5-dimethyl-3-hexene
AU - Takano, Seiichi
AU - Iwabuchi, Yoshiharu
AU - Ogasawara, Kunio
N1 - Funding Information:
Acknowledgements: We are grateful to Professor K. B. Sharpless, Massachusetts Institute of Technology, for sending us a manuscript copy of ref. 2c. We also thank the Ministry of Education, Science and Culture, Japan, for financial support of this research and Fellowships of the Japan Society for Promotion of Science for Japanese Junior Scientists (to Y. I.).
PY - 1991/7/15
Y1 - 1991/7/15
N2 - The first asymmetric epoxidation of a tertiary allylic alcohol by the Katsuki-Sharpless reaction has been demonstrated using (E)-2,5-dihydroxy-2,5- dimethyl-3-hexene as a tertiary allylic alcohol substrate to afford optically active 3,4- epoxy-2,5-dihydroxy-2,5-dimethylhexane in 70% ee in an excellent chemical yield.
AB - The first asymmetric epoxidation of a tertiary allylic alcohol by the Katsuki-Sharpless reaction has been demonstrated using (E)-2,5-dihydroxy-2,5- dimethyl-3-hexene as a tertiary allylic alcohol substrate to afford optically active 3,4- epoxy-2,5-dihydroxy-2,5-dimethylhexane in 70% ee in an excellent chemical yield.
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U2 - 10.1016/0040-4039(91)80823-O
DO - 10.1016/0040-4039(91)80823-O
M3 - Article
AN - SCOPUS:0025732821
SN - 0040-4039
VL - 32
SP - 3527
EP - 3528
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 29
ER -