The Katsuki-Sharpless asymmetric epoxidation of (E)-2,5-dihydroxy-2,5-dimethyl-3-hexene

Seiichi Takano, Yoshiharu Iwabuchi, Kunio Ogasawara

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


The first asymmetric epoxidation of a tertiary allylic alcohol by the Katsuki-Sharpless reaction has been demonstrated using (E)-2,5-dihydroxy-2,5- dimethyl-3-hexene as a tertiary allylic alcohol substrate to afford optically active 3,4- epoxy-2,5-dihydroxy-2,5-dimethylhexane in 70% ee in an excellent chemical yield.

Original languageEnglish
Pages (from-to)3527-3528
Number of pages2
JournalTetrahedron Letters
Issue number29
Publication statusPublished - 1991 Jul 15


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