The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling

Hiroyuki Kanzaki; Fumiaki Shinohara; Mikihito Kajiya; Tetsuya Kodama

doi:10.1074/jbc.M113.478545

The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling

Hiroyuki Kanzaki, Fumiaki Shinohara, Mikihito Kajiya, Tetsuya Kodama

MEN - Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

124 Citations (Scopus)

Abstract

Background: Nuclear factor E2-related factor 2 (Nrf2) is a master regulator of cytoprotective enzymes. Results: Nrf2 overexpression-mediated cytoprotective enzymes' augmentation blocked RANKL signaling via intracellular ROS attenuation and thereby blocked bone destruction. Conclusion: Nrf2-dependent cytoprotective enzyme expressions play a role in the regulation of osteoclastogenesis by controlling intracellular ROS. Significance: The Keap1/Nrf2 axis could be a novel therapeutic target for the treatment of bone destructive disease.

Original language	English
Pages (from-to)	23009-23020
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M113.478545
Publication status	Published - 2013 Aug 9

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abstract = "Background: Nuclear factor E2-related factor 2 (Nrf2) is a master regulator of cytoprotective enzymes. Results: Nrf2 overexpression-mediated cytoprotective enzymes' augmentation blocked RANKL signaling via intracellular ROS attenuation and thereby blocked bone destruction. Conclusion: Nrf2-dependent cytoprotective enzyme expressions play a role in the regulation of osteoclastogenesis by controlling intracellular ROS. Significance: The Keap1/Nrf2 axis could be a novel therapeutic target for the treatment of bone destructive disease.",

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AU - Kanzaki, Hiroyuki

AU - Shinohara, Fumiaki

AU - Kajiya, Mikihito

AU - Kodama, Tetsuya

PY - 2013/8/9

Y1 - 2013/8/9

N2 - Background: Nuclear factor E2-related factor 2 (Nrf2) is a master regulator of cytoprotective enzymes. Results: Nrf2 overexpression-mediated cytoprotective enzymes' augmentation blocked RANKL signaling via intracellular ROS attenuation and thereby blocked bone destruction. Conclusion: Nrf2-dependent cytoprotective enzyme expressions play a role in the regulation of osteoclastogenesis by controlling intracellular ROS. Significance: The Keap1/Nrf2 axis could be a novel therapeutic target for the treatment of bone destructive disease.

AB - Background: Nuclear factor E2-related factor 2 (Nrf2) is a master regulator of cytoprotective enzymes. Results: Nrf2 overexpression-mediated cytoprotective enzymes' augmentation blocked RANKL signaling via intracellular ROS attenuation and thereby blocked bone destruction. Conclusion: Nrf2-dependent cytoprotective enzyme expressions play a role in the regulation of osteoclastogenesis by controlling intracellular ROS. Significance: The Keap1/Nrf2 axis could be a novel therapeutic target for the treatment of bone destructive disease.

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The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling

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