The magnitude and duration of cyclic stretch affect JNK and p38 activation in MC3T3-E1 pre-osteoblastic cells

Hiroyuki Matsui; Naoto Fukuno; Keiichi Sasaki; Osamu Suzuki; Takayasu Kobayashi; Shinri Tamura

doi:10.1109/MHS.2007.4420849

The magnitude and duration of cyclic stretch affect JNK and p38 activation in MC3T3-E1 pre-osteoblastic cells

Hiroyuki Matsui, Naoto Fukuno, Keiichi Sasaki, Osamu Suzuki, Takayasu Kobayashi, Shinri Tamura

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

Although mechanical stress has been shown to regulate bone modeling and remodeling, the mechanisms of bone remodeling after mechanical stress loading are not fully understood. In this study we determined the effects of cyclic mechanical stretch of varying magnitudes and durations on the activation of JNK and p38 in MC3T3-E1 cells. Phosphorylation of both JNK and p38 was observed 5 min after the onset of stretch-load and increased proportionally with elongation. However, a marked increase in the phosphorylation of p38 but not JNK was observed when cells were stretched to 4% elongation. These observations raise the possibility that JNK and p38 play different roles in bone remodeling depending on the magnitude and duration of mechanical stretch.

Original language	English
Title of host publication	2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS
Pages	183-186
Number of pages	4
DOIs	https://doi.org/10.1109/MHS.2007.4420849
Publication status	Published - 2007
Event	2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS - Nagoya, Japan Duration: 2007 Nov 11 → 2007 Nov 14

Publication series

Name	2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS

Other

Other	2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS
Country/Territory	Japan
City	Nagoya
Period	07/11/11 → 07/11/14

ASJC Scopus subject areas

Artificial Intelligence
Computer Networks and Communications
Human-Computer Interaction
Electrical and Electronic Engineering

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10.1109/MHS.2007.4420849

Cite this

Matsui, H., Fukuno, N., Sasaki, K., Suzuki, O., Kobayashi, T., & Tamura, S. (2007). The magnitude and duration of cyclic stretch affect JNK and p38 activation in MC3T3-E1 pre-osteoblastic cells. In 2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS (pp. 183-186). [4420849] (2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS). https://doi.org/10.1109/MHS.2007.4420849

The magnitude and duration of cyclic stretch affect JNK and p38 activation in MC3T3-E1 pre-osteoblastic cells. / Matsui, Hiroyuki; Fukuno, Naoto; Sasaki, Keiichi et al.
2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS. 2007. p. 183-186 4420849 (2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Matsui, H, Fukuno, N, Sasaki, K , Suzuki, O , Kobayashi, T & Tamura, S 2007, The magnitude and duration of cyclic stretch affect JNK and p38 activation in MC3T3-E1 pre-osteoblastic cells. in 2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS., 4420849, 2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS, pp. 183-186, 2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS, Nagoya, Japan, 07/11/11. https://doi.org/10.1109/MHS.2007.4420849

Matsui H, Fukuno N, Sasaki K , Suzuki O , Kobayashi T, Tamura S. The magnitude and duration of cyclic stretch affect JNK and p38 activation in MC3T3-E1 pre-osteoblastic cells. In 2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS. 2007. p. 183-186. 4420849. (2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS). doi: 10.1109/MHS.2007.4420849

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abstract = "Although mechanical stress has been shown to regulate bone modeling and remodeling, the mechanisms of bone remodeling after mechanical stress loading are not fully understood. In this study we determined the effects of cyclic mechanical stretch of varying magnitudes and durations on the activation of JNK and p38 in MC3T3-E1 cells. Phosphorylation of both JNK and p38 was observed 5 min after the onset of stretch-load and increased proportionally with elongation. However, a marked increase in the phosphorylation of p38 but not JNK was observed when cells were stretched to 4% elongation. These observations raise the possibility that JNK and p38 play different roles in bone remodeling depending on the magnitude and duration of mechanical stretch.",

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AU - Sasaki, Keiichi

AU - Suzuki, Osamu

AU - Kobayashi, Takayasu

AU - Tamura, Shinri

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AB - Although mechanical stress has been shown to regulate bone modeling and remodeling, the mechanisms of bone remodeling after mechanical stress loading are not fully understood. In this study we determined the effects of cyclic mechanical stretch of varying magnitudes and durations on the activation of JNK and p38 in MC3T3-E1 cells. Phosphorylation of both JNK and p38 was observed 5 min after the onset of stretch-load and increased proportionally with elongation. However, a marked increase in the phosphorylation of p38 but not JNK was observed when cells were stretched to 4% elongation. These observations raise the possibility that JNK and p38 play different roles in bone remodeling depending on the magnitude and duration of mechanical stretch.

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The magnitude and duration of cyclic stretch affect JNK and p38 activation in MC3T3-E1 pre-osteoblastic cells

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