The mammalian homolog of the Drosophila discs large tumor suppressor protein up-regulates expression of the ELR+ CXC chemokine Scyb5

Tomoiki Aiba; Kazuyoshi Kohu; Takefumi Ishidao; Naomi Yasui; Akira Horii; Hiroyuki Aburatani; Tetsu Akiyama

doi:10.1016/j.bbrc.2005.09.037

The mammalian homolog of the Drosophila discs large tumor suppressor protein up-regulates expression of the ELR⁺ CXC chemokine Scyb5

Tomoiki Aiba, Kazuyoshi Kohu, Takefumi Ishidao, Naomi Yasui, Akira Horii, Hiroyuki Aburatani, Tetsu Akiyama

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The mammalian homolog of the Drosophila discs large tumor suppressor protein Dlg functions as a scaffolding protein that facilitates the transmission of diverse signals. In the present study, we attempted to identify the downstream target genes of Dlg, and found that Dlg up-regulates expression of the ELR⁺ CXC chemokine Scyb5, which has been implicated in the immune system. Our finding suggests that Scyb5 may play an important role in the tumor suppressor function of Dlg.

Original language	English
Pages (from-to)	191-194
Number of pages	4
Journal	Biochemical and biophysical research communications
Volume	337
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2005.09.037
Publication status	Published - 2005 Nov 11

Keywords

Discs large
Dlg
MAGUK
Microarray
Scaffolding protein
Scyb5
Tumor suppressor

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1016/j.bbrc.2005.09.037

Cite this

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title = "The mammalian homolog of the Drosophila discs large tumor suppressor protein up-regulates expression of the ELR+ CXC chemokine Scyb5",

abstract = "The mammalian homolog of the Drosophila discs large tumor suppressor protein Dlg functions as a scaffolding protein that facilitates the transmission of diverse signals. In the present study, we attempted to identify the downstream target genes of Dlg, and found that Dlg up-regulates expression of the ELR+ CXC chemokine Scyb5, which has been implicated in the immune system. Our finding suggests that Scyb5 may play an important role in the tumor suppressor function of Dlg.",

keywords = "Discs large, Dlg, MAGUK, Microarray, Scaffolding protein, Scyb5, Tumor suppressor",

author = "Tomoiki Aiba and Kazuyoshi Kohu and Takefumi Ishidao and Naomi Yasui and Akira Horii and Hiroyuki Aburatani and Tetsu Akiyama",

note = "Funding Information: We thank K. Matsuura for reading the manuscript. This work was supported by Grants-in-Aid for Scientific Research on Priority Areas and the Organization for Pharmaceutical Safety and Research.",

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AU - Kohu, Kazuyoshi

AU - Ishidao, Takefumi

AU - Yasui, Naomi

AU - Horii, Akira

AU - Aburatani, Hiroyuki

AU - Akiyama, Tetsu

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