The many faces of Sox2 function in neural crest development

Yoshio Wakamatsu; Masanori Uchikawa

doi:10.1111/dgd.12705

The many faces of Sox2 function in neural crest development

Yoshio Wakamatsu, Masanori Uchikawa

MED - United Centers for Advanced Research and Translational Medicine (ART)

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

Neural crest (NC) cells give rise to a wide variety of cell types and tissues, such as neurons and glial cells in the peripheral nervous system. Sox2, which encodes an HMG-box transcription factor, is known to mediate pluripotency of primordial germ cells and embryonic stem (ES)/induced pluripotent stem (iPS) cells, and to regulate central nervous system development. Previous studies have revealed that Sox2 is also an important regulator of NC development. This review summarizes the well-established inhibitory roles of Sox2 in NC formation and subsequent neuronal differentiation of NC-derived cells. This review also covers recent studies suggesting additional roles for Sox2 in early NC development, neurogenesis, and glial differentiation of NC-derived cells.

Original language	English
Pages (from-to)	93-99
Number of pages	7
Journal	Development Growth and Differentiation
Volume	63
Issue number	1
DOIs	https://doi.org/10.1111/dgd.12705
Publication status	Published - 2021 Jan

Keywords

N-cadherin
Notch
Pax7
Schwann cell
Sox10
Sox2
dorsal root ganglia
epithelial–mesenchymal transition
neural crest
sensory neuron

ASJC Scopus subject areas

Developmental Biology
Cell Biology

Access to Document

10.1111/dgd.12705

Cite this

@article{34b1f08a5a6e4abda356b5d83b4ca5b7,

title = "The many faces of Sox2 function in neural crest development",

abstract = "Neural crest (NC) cells give rise to a wide variety of cell types and tissues, such as neurons and glial cells in the peripheral nervous system. Sox2, which encodes an HMG-box transcription factor, is known to mediate pluripotency of primordial germ cells and embryonic stem (ES)/induced pluripotent stem (iPS) cells, and to regulate central nervous system development. Previous studies have revealed that Sox2 is also an important regulator of NC development. This review summarizes the well-established inhibitory roles of Sox2 in NC formation and subsequent neuronal differentiation of NC-derived cells. This review also covers recent studies suggesting additional roles for Sox2 in early NC development, neurogenesis, and glial differentiation of NC-derived cells.",

keywords = "N-cadherin, Notch, Pax7, Schwann cell, Sox10, Sox2, dorsal root ganglia, epithelial–mesenchymal transition, neural crest, sensory neuron",

author = "Yoshio Wakamatsu and Masanori Uchikawa",

note = "Funding Information: We thank Drs. Hisato Kondoh and Thomas Maynard for comments on the manuscript. This work was supported in part by JSPS grants to YW (KAKENHI grant no. 20K06651), and to MU (KAKENHI grant no. 16K07370). Publisher Copyright: {\textcopyright} 2020 Japanese Society of Developmental Biologists",

year = "2021",

month = jan,

doi = "10.1111/dgd.12705",

language = "English",

volume = "63",

pages = "93--99",

journal = "Development Growth and Differentiation",

issn = "0012-1592",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - The many faces of Sox2 function in neural crest development

AU - Wakamatsu, Yoshio

AU - Uchikawa, Masanori

N1 - Funding Information: We thank Drs. Hisato Kondoh and Thomas Maynard for comments on the manuscript. This work was supported in part by JSPS grants to YW (KAKENHI grant no. 20K06651), and to MU (KAKENHI grant no. 16K07370). Publisher Copyright: © 2020 Japanese Society of Developmental Biologists

PY - 2021/1

Y1 - 2021/1

N2 - Neural crest (NC) cells give rise to a wide variety of cell types and tissues, such as neurons and glial cells in the peripheral nervous system. Sox2, which encodes an HMG-box transcription factor, is known to mediate pluripotency of primordial germ cells and embryonic stem (ES)/induced pluripotent stem (iPS) cells, and to regulate central nervous system development. Previous studies have revealed that Sox2 is also an important regulator of NC development. This review summarizes the well-established inhibitory roles of Sox2 in NC formation and subsequent neuronal differentiation of NC-derived cells. This review also covers recent studies suggesting additional roles for Sox2 in early NC development, neurogenesis, and glial differentiation of NC-derived cells.

AB - Neural crest (NC) cells give rise to a wide variety of cell types and tissues, such as neurons and glial cells in the peripheral nervous system. Sox2, which encodes an HMG-box transcription factor, is known to mediate pluripotency of primordial germ cells and embryonic stem (ES)/induced pluripotent stem (iPS) cells, and to regulate central nervous system development. Previous studies have revealed that Sox2 is also an important regulator of NC development. This review summarizes the well-established inhibitory roles of Sox2 in NC formation and subsequent neuronal differentiation of NC-derived cells. This review also covers recent studies suggesting additional roles for Sox2 in early NC development, neurogenesis, and glial differentiation of NC-derived cells.

KW - N-cadherin

KW - Notch

KW - Pax7

KW - Schwann cell

KW - Sox10

KW - Sox2

KW - dorsal root ganglia

KW - epithelial–mesenchymal transition

KW - neural crest

KW - sensory neuron

UR - http://www.scopus.com/inward/record.url?scp=85099210236&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85099210236&partnerID=8YFLogxK

U2 - 10.1111/dgd.12705

DO - 10.1111/dgd.12705

M3 - Review article

C2 - 33326593

AN - SCOPUS:85099210236

SN - 0012-1592

VL - 63

SP - 93

EP - 99

JO - Development Growth and Differentiation

JF - Development Growth and Differentiation

IS - 1

ER -

The many faces of Sox2 function in neural crest development

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this