The many faces of Sox2 function in neural crest development

Yoshio Wakamatsu, Masanori Uchikawa

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)


Neural crest (NC) cells give rise to a wide variety of cell types and tissues, such as neurons and glial cells in the peripheral nervous system. Sox2, which encodes an HMG-box transcription factor, is known to mediate pluripotency of primordial germ cells and embryonic stem (ES)/induced pluripotent stem (iPS) cells, and to regulate central nervous system development. Previous studies have revealed that Sox2 is also an important regulator of NC development. This review summarizes the well-established inhibitory roles of Sox2 in NC formation and subsequent neuronal differentiation of NC-derived cells. This review also covers recent studies suggesting additional roles for Sox2 in early NC development, neurogenesis, and glial differentiation of NC-derived cells.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalDevelopment Growth and Differentiation
Issue number1
Publication statusPublished - 2021 Jan


  • N-cadherin
  • Notch
  • Pax7
  • Schwann cell
  • Sox10
  • Sox2
  • dorsal root ganglia
  • epithelial–mesenchymal transition
  • neural crest
  • sensory neuron

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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