The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis

Yosuke Funato, Atsushi Yoshida, Yusuke Hirata, Osamu Hashizume, Daisuke Yamazaki, Hiroaki Miki

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Mammalian cells proliferate most efficiently at around pH 7.4. Funato et al. show that cells expressing the oncogene phosphatase of regenerating liver (PRL), which stimulates H+ extrusion by lysosomal exocytosis, shift their optimum pH to acidic 6.5. This phenotype is beneficial for cancer cells to proliferate in the acidic tumor microenvironment.

Original languageEnglish
Pages (from-to)387-397.e8
JournalDevelopmental Cell
Volume55
Issue number4
DOIs
Publication statusPublished - 2020 Nov 23

Keywords

  • PRL
  • TRPML
  • acid addiction
  • lysosomal exocytosis
  • phosphatase of regenerating liver
  • transient receptor potential mucolipin
  • tumor microenvironment

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