The regulation of adipogenesis through GPR120

Chizu Gotoh; Yeon Hee Hong; Tomoyo Iga; Daisuke Hishikawa; Yasuki Suzuki; Sang Houn Song; Ki Choon Choi; Tetsuya Adachi; Akira Hirasawa; Gozoh Tsujimoto; Shin ichi Sasaki; Sang Gun Roh

doi:10.1016/j.bbrc.2007.01.028

The regulation of adipogenesis through GPR120

Chizu Gotoh, Yeon Hee Hong, Tomoyo Iga, Daisuke Hishikawa, Yasuki Suzuki, Sang Houn Song, Ki Choon Choi, Tetsuya Adachi, Akira Hirasawa, Gozoh Tsujimoto, Shin ichi Sasaki, Sang Gun Roh

AGR - Agricultural Bioscience

Research output: Contribution to journal › Article › peer-review

202 Citations (Scopus)

Abstract

Recently, it has been found that long-chain fatty acids activate the G protein-coupled receptors (GPRs), GPR120 and GPR40. However, there have been no reports to date on the possible physiological roles of these GPRs in adipose tissue development and adipocyte differentiation. GPR120 mRNA was highly expressed in the four different adipose tissues, and the amount of mRNA was elevated in adipose tissues of mice fed a high fat diet. However, GPR40 mRNA was not detected in any of the adipose tissues. The expression of GPR120 mRNA was higher in adipocytes compared to stromal-vascular (S-V) cells. The level of GPR120 mRNA increased during adipocyte differentiation in 3T3-L1 cells. Similar results were observed in human adipose tissue, human preadipocytes, and cultured adipocytes. Moreover, use of a small interference RNA (siRNA) to down-regulate GPR120 expression resulted in inhibition of adipocyte differentiation. Our results suggest that GPR120 regulates adipogenic processes such as adipocyte development and differentiation.

Original language	English
Pages (from-to)	591-597
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	354
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2007.01.028
Publication status	Published - 2007 Mar 9

Keywords

Adipogenesis
GPR120
GPR40
Long-chain fatty acids

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10.1016/j.bbrc.2007.01.028

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title = "The regulation of adipogenesis through GPR120",

abstract = "Recently, it has been found that long-chain fatty acids activate the G protein-coupled receptors (GPRs), GPR120 and GPR40. However, there have been no reports to date on the possible physiological roles of these GPRs in adipose tissue development and adipocyte differentiation. GPR120 mRNA was highly expressed in the four different adipose tissues, and the amount of mRNA was elevated in adipose tissues of mice fed a high fat diet. However, GPR40 mRNA was not detected in any of the adipose tissues. The expression of GPR120 mRNA was higher in adipocytes compared to stromal-vascular (S-V) cells. The level of GPR120 mRNA increased during adipocyte differentiation in 3T3-L1 cells. Similar results were observed in human adipose tissue, human preadipocytes, and cultured adipocytes. Moreover, use of a small interference RNA (siRNA) to down-regulate GPR120 expression resulted in inhibition of adipocyte differentiation. Our results suggest that GPR120 regulates adipogenic processes such as adipocyte development and differentiation.",

keywords = "Adipogenesis, GPR120, GPR40, Long-chain fatty acids",

author = "Chizu Gotoh and Hong, {Yeon Hee} and Tomoyo Iga and Daisuke Hishikawa and Yasuki Suzuki and Song, {Sang Houn} and Choi, {Ki Choon} and Tetsuya Adachi and Akira Hirasawa and Gozoh Tsujimoto and Sasaki, {Shin ichi} and Roh, {Sang Gun}",

note = "Funding Information: This work was partly supported by Grant-in-Aid (No. 17380168 to Sang-Gun Roh) for scientific research from the Ministry of Education, Science, Sports and Culture of Japan.",

year = "2007",

month = mar,

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doi = "10.1016/j.bbrc.2007.01.028",

language = "English",

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journal = "Biochemical and Biophysical Research Communications",

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T1 - The regulation of adipogenesis through GPR120

AU - Gotoh, Chizu

AU - Hong, Yeon Hee

AU - Iga, Tomoyo

AU - Hishikawa, Daisuke

AU - Suzuki, Yasuki

AU - Song, Sang Houn

AU - Choi, Ki Choon

AU - Adachi, Tetsuya

AU - Hirasawa, Akira

AU - Tsujimoto, Gozoh

AU - Sasaki, Shin ichi

AU - Roh, Sang Gun

N1 - Funding Information: This work was partly supported by Grant-in-Aid (No. 17380168 to Sang-Gun Roh) for scientific research from the Ministry of Education, Science, Sports and Culture of Japan.

PY - 2007/3/9

Y1 - 2007/3/9

N2 - Recently, it has been found that long-chain fatty acids activate the G protein-coupled receptors (GPRs), GPR120 and GPR40. However, there have been no reports to date on the possible physiological roles of these GPRs in adipose tissue development and adipocyte differentiation. GPR120 mRNA was highly expressed in the four different adipose tissues, and the amount of mRNA was elevated in adipose tissues of mice fed a high fat diet. However, GPR40 mRNA was not detected in any of the adipose tissues. The expression of GPR120 mRNA was higher in adipocytes compared to stromal-vascular (S-V) cells. The level of GPR120 mRNA increased during adipocyte differentiation in 3T3-L1 cells. Similar results were observed in human adipose tissue, human preadipocytes, and cultured adipocytes. Moreover, use of a small interference RNA (siRNA) to down-regulate GPR120 expression resulted in inhibition of adipocyte differentiation. Our results suggest that GPR120 regulates adipogenic processes such as adipocyte development and differentiation.

AB - Recently, it has been found that long-chain fatty acids activate the G protein-coupled receptors (GPRs), GPR120 and GPR40. However, there have been no reports to date on the possible physiological roles of these GPRs in adipose tissue development and adipocyte differentiation. GPR120 mRNA was highly expressed in the four different adipose tissues, and the amount of mRNA was elevated in adipose tissues of mice fed a high fat diet. However, GPR40 mRNA was not detected in any of the adipose tissues. The expression of GPR120 mRNA was higher in adipocytes compared to stromal-vascular (S-V) cells. The level of GPR120 mRNA increased during adipocyte differentiation in 3T3-L1 cells. Similar results were observed in human adipose tissue, human preadipocytes, and cultured adipocytes. Moreover, use of a small interference RNA (siRNA) to down-regulate GPR120 expression resulted in inhibition of adipocyte differentiation. Our results suggest that GPR120 regulates adipogenic processes such as adipocyte development and differentiation.

KW - Adipogenesis

KW - GPR120

KW - GPR40

KW - Long-chain fatty acids

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The regulation of adipogenesis through GPR120

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