The relationship between the arterial inner diameter, the balloon's outer diameter and the volume of infused adhesive, and the evaluation of cases using viscous adhesive in Intracoronary Local Adhesive Delivery Technique

For the problem of acute coronary occlusion, we designed the intracoronary adhesive delivery technique by which we can form a resinous stent of adhesive on the arterial inner wall with the lesion segment using antithrombotic adhesive and a flexible drug delivery PTCA (Percutaneous Transluminal Coronary Angioplasty) catheter. In this acute animal experiment, using femoral arteries and renal arteries of adult goats in order to ensure the tunnel formation of adhesive, we studied the relationship between the arterial inner diameter, the balloon's outer diameter, and the volume of infused adhesive, and evaluated some cases using the slightly viscous adhesive in this method. When the R, which is the ratio of the arterial inner diameter to the balloon's outer diameter, was within the range of 0.9≤R≤1.0, we could make resinous stents in most cases. In successful cases it seemed that the volume of infused adhesive depends on the arterial stretching degree at the time of adhesive's delivery. That stretching, where the volume is no longer related to the R from the viewpoint of the success or failure of tunnel formation, existed in either cases of the balloon oversize or undersize to the arterial inner diameter. When we used high viscous adhesives, the adhesive's delivery using existing catheters was difficult.