The relationships between autonomic function and heart rate in essential hypertension

Noriko Ohisa, Junichiro Hashimoto, Katsumi Yoshida, Yutaka Imai, Mitsuo Kaku

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The circadian variation of blood pressure (BP) may be mediated at least in part by circadian variation of autonomic nervous system activity. In the present study power spectral analysis of hourly R-R intervals for 24 hours was done to obtain the low frequency variability (LF: 0.04 to 0.15Hz) and high frequency variability(HF: 0.15 to 0.40Hz) in 93 patients with untreated essential hypertension. LF/HF ratio and HF were considered to be an index of sympathetic nervous activity and parasympathetic nervous activity, respectively. The relationship between heart rate (HR) and systolic blood pressure (SBP), diastolic blood pressure (DBP), HF, and LF/HF was examined. Both SBP and DBP were correlated positively with HR(r = 0.28, p < 0.05 and r = 0.27, p < 0.05, respectively) in the daytime. HF was correlated negatively and significantly with HR in both daytime and nighttime (r = -0.40, p < 0.05, and r = -0.38, p < 0.05 respectively). After averaging for SBP of 24 hours, HR in the patients whose SBP was 135mmHg or more was significantly higher than that in the patients whose SBP was less than 135mmHg. These results suggest that the decreased parasympathetic nervous activity seems to be responsible for the rise in BP.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalRinsho byori. The Japanese journal of clinical pathology
Issue number3
Publication statusPublished - 2005 Mar

ASJC Scopus subject areas

  • Medicine(all)


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