@article{41f4d80e2f5041c78f96fdaac1d1651a,
title = "The ribosome collision sensor Hel2 functions as preventive quality control in the secretory pathway",
abstract = "Matsuo and Inada utilize selective ribosome profiling to survey endogenous substrates for Hel2 and find that Hel2 preferentially binds to pre-engaged secretory RNCs lacking SRP recognition. They also show that Hel2-mediated quality control contributes to alleviation of mistargeting of secretory proteins into mitochondria caused by loss of the SRP.",
keywords = "ER, Hel2, SRP, mitochondria, protein mislocalization, protein targeting, quality control, ribosome collision, ribosome stalling, ribosome ubiquitination",
author = "Yoshitaka Matsuo and Toshifumi Inada",
note = "Funding Information: Part of this work was performed at the Vincent J. Coates Genomics Sequencing Laboratory at UC Berkeley, supported by NIH S10 Instrumentation Grant OD018174 . Computations were performed partially on the NIG supercomputer at the ROIS National Institute of Genetics. This study was supported by a Grants-in-Aid for Scientific Research (KAKENHI) from the Japan Society for the Promotion of Science ( 18H03977 to T.I. and 19K06481 to Y.M.), AMED under grant JP 19gm1110010 (T.I.), and research grants from the Mochida Memorial Foundation for Medical and Pharmaceutical Research (to Y.M.) and the Takeda Science Foundation (to T.I.). Publisher Copyright: {\textcopyright} 2021 The Author(s)",
year = "2021",
month = mar,
day = "23",
doi = "10.1016/j.celrep.2021.108877",
language = "English",
volume = "34",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "12",
}