The role of AGE–RAGE system in the development of diabetic nephropathy in vivo

Yasuhiko Yamamoto, Ichiro Kato, Toshio Doi, Hideto Yonekura, Seiji Ohashi, Masayoshi Takeuchi, Takuo Watanabe, Shigeru Sakurai, Kiyoshi Yasui, Ralica G. Petrova, Md Joynal Abedin, Hui Li, A. Azadur Rahman, Shin Takasawa, Hiroshi Okamoto, Hiroshi Yamamoto

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Vascular complications are what eventually threaten the lives of diabetic patients. Here we show direct in vivo evidence that the interaction between advanced glycation end products (AGE), the formation of which is accelerated during prolonged hyperglycemic exposure, and a cell surface receptor for AGE (RAGE) is the major cause of such complications. We created transgenic mice that overexpress human RAGE in vascular cells and crossbred them with another transgenic line which develops insulin-dependent diabetes early after birth. The resultant double transgenic mice exhibited accelerated kidney changes compared with single transgenic littermates, and the nephropathy was ameliorated by an inhibitor of AGE formation. The AGE–RAGE system will thus be a promising target for overcoming diabetic complications.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalInternational Congress Series
Issue numberC
Publication statusPublished - 2002


  • Diabetes
  • Diabetic nephropathy
  • Glycation
  • RAGE
  • Transgenic mouse


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