The role of an octacalcium phosphate in the re-formation of infraspinatus tendon insertion

Yoshiaki Itoigawa; Osamu Suzuki; Hirotaka Sano; Takahisa Anada; Takuto Handa; Taku Hatta; Yoshiyuki Kuwahara; Atsushi Takahashi; Yushi Ezoe; Kazuo Kaneko; Eiji Itoi

doi:10.1016/j.jse.2015.01.011

The role of an octacalcium phosphate in the re-formation of infraspinatus tendon insertion

Yoshiaki Itoigawa, Osamu Suzuki, Hirotaka Sano, Takahisa Anada, Takuto Handa, Taku Hatta, Yoshiyuki Kuwahara, Atsushi Takahashi, Yushi Ezoe, Kazuo Kaneko, Eiji Itoi

DEN - Dental Sciences

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Background: To improve the success rate of rotator cuff repair, we investigated whether octacalcium phosphate (OCP) with gelatin (Gel) vehicle had a positive effect on tendon-to-bone healing. Methods: We assessed the histologic characteristics of the tendon-to-bone healing using the rabbit rotator cuff repair model. We divided the shoulders into 3 groups: control (without OCP/Gel composite), OCP/Gel composite (OCP+group), and Gel alone without OCP (Gel group) to evaluate the effectiveness of gelatin. Results: Both the number of newly formed tendon fibers and the Sharpey fibers at the repair site increased in the OCP+group compared with those in the other 2 groups on hematoxylin-eosin staining (P<.05). On immunohistochemical evaluation, both the bone and the fibers in the OCP+group demonstrated that type I collagen was picked up, whereas the newly formed tendon fibers and Sharpey fibers revealed type III collagen. Conclusion: Treatment with OCP made collagen fibers and the Sharpey fibers, constituted by type I and type III collagens, increase at the tendon-to-bone insertion. It might be beneficial for the healing of rotator cuff tendon to bone.

Original language	English
Pages (from-to)	e175-e184
Journal	Journal of Shoulder and Elbow Surgery
Volume	24
Issue number	7
DOIs	https://doi.org/10.1016/j.jse.2015.01.011
Publication status	Published - 2015 Jul 1

Keywords

Basic Science Study
Collagen fibers
Enthesis
Histology
Octacalcium phosphate (OCP)
Rotator cuff repair
Sharpey fibers
Shoulder
Tendon-to-bone healing

Access to Document

10.1016/j.jse.2015.01.011

Cite this

@article{d513077aa8404fb2934602d4a476f8e3,

title = "The role of an octacalcium phosphate in the re-formation of infraspinatus tendon insertion",

abstract = "Background: To improve the success rate of rotator cuff repair, we investigated whether octacalcium phosphate (OCP) with gelatin (Gel) vehicle had a positive effect on tendon-to-bone healing. Methods: We assessed the histologic characteristics of the tendon-to-bone healing using the rabbit rotator cuff repair model. We divided the shoulders into 3 groups: control (without OCP/Gel composite), OCP/Gel composite (OCP+group), and Gel alone without OCP (Gel group) to evaluate the effectiveness of gelatin. Results: Both the number of newly formed tendon fibers and the Sharpey fibers at the repair site increased in the OCP+group compared with those in the other 2 groups on hematoxylin-eosin staining (P<.05). On immunohistochemical evaluation, both the bone and the fibers in the OCP+group demonstrated that type I collagen was picked up, whereas the newly formed tendon fibers and Sharpey fibers revealed type III collagen. Conclusion: Treatment with OCP made collagen fibers and the Sharpey fibers, constituted by type I and type III collagens, increase at the tendon-to-bone insertion. It might be beneficial for the healing of rotator cuff tendon to bone.",

keywords = "Basic Science Study, Collagen fibers, Enthesis, Histology, Octacalcium phosphate (OCP), Rotator cuff repair, Sharpey fibers, Shoulder, Tendon-to-bone healing",

author = "Yoshiaki Itoigawa and Osamu Suzuki and Hirotaka Sano and Takahisa Anada and Takuto Handa and Taku Hatta and Yoshiyuki Kuwahara and Atsushi Takahashi and Yushi Ezoe and Kazuo Kaneko and Eiji Itoi",

note = "Publisher Copyright: {\textcopyright} 2015 Journal of Shoulder and Elbow Surgery Board of Trustees.",

year = "2015",

month = jul,

day = "1",

doi = "10.1016/j.jse.2015.01.011",

language = "English",

volume = "24",

pages = "e175--e184",

journal = "Journal of Shoulder and Elbow Surgery",

issn = "1058-2746",

publisher = "Mosby Inc.",

number = "7",

}

TY - JOUR

T1 - The role of an octacalcium phosphate in the re-formation of infraspinatus tendon insertion

AU - Itoigawa, Yoshiaki

AU - Suzuki, Osamu

AU - Sano, Hirotaka

AU - Anada, Takahisa

AU - Handa, Takuto

AU - Hatta, Taku

AU - Kuwahara, Yoshiyuki

AU - Takahashi, Atsushi

AU - Ezoe, Yushi

AU - Kaneko, Kazuo

AU - Itoi, Eiji

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Background: To improve the success rate of rotator cuff repair, we investigated whether octacalcium phosphate (OCP) with gelatin (Gel) vehicle had a positive effect on tendon-to-bone healing. Methods: We assessed the histologic characteristics of the tendon-to-bone healing using the rabbit rotator cuff repair model. We divided the shoulders into 3 groups: control (without OCP/Gel composite), OCP/Gel composite (OCP+group), and Gel alone without OCP (Gel group) to evaluate the effectiveness of gelatin. Results: Both the number of newly formed tendon fibers and the Sharpey fibers at the repair site increased in the OCP+group compared with those in the other 2 groups on hematoxylin-eosin staining (P<.05). On immunohistochemical evaluation, both the bone and the fibers in the OCP+group demonstrated that type I collagen was picked up, whereas the newly formed tendon fibers and Sharpey fibers revealed type III collagen. Conclusion: Treatment with OCP made collagen fibers and the Sharpey fibers, constituted by type I and type III collagens, increase at the tendon-to-bone insertion. It might be beneficial for the healing of rotator cuff tendon to bone.

AB - Background: To improve the success rate of rotator cuff repair, we investigated whether octacalcium phosphate (OCP) with gelatin (Gel) vehicle had a positive effect on tendon-to-bone healing. Methods: We assessed the histologic characteristics of the tendon-to-bone healing using the rabbit rotator cuff repair model. We divided the shoulders into 3 groups: control (without OCP/Gel composite), OCP/Gel composite (OCP+group), and Gel alone without OCP (Gel group) to evaluate the effectiveness of gelatin. Results: Both the number of newly formed tendon fibers and the Sharpey fibers at the repair site increased in the OCP+group compared with those in the other 2 groups on hematoxylin-eosin staining (P<.05). On immunohistochemical evaluation, both the bone and the fibers in the OCP+group demonstrated that type I collagen was picked up, whereas the newly formed tendon fibers and Sharpey fibers revealed type III collagen. Conclusion: Treatment with OCP made collagen fibers and the Sharpey fibers, constituted by type I and type III collagens, increase at the tendon-to-bone insertion. It might be beneficial for the healing of rotator cuff tendon to bone.

KW - Basic Science Study

KW - Collagen fibers

KW - Enthesis

KW - Histology

KW - Octacalcium phosphate (OCP)

KW - Rotator cuff repair

KW - Sharpey fibers

KW - Shoulder

KW - Tendon-to-bone healing

UR - http://www.scopus.com/inward/record.url?scp=84930537513&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930537513&partnerID=8YFLogxK

U2 - 10.1016/j.jse.2015.01.011

DO - 10.1016/j.jse.2015.01.011

M3 - Article

C2 - 25825137

AN - SCOPUS:84930537513

SN - 1058-2746

VL - 24

SP - e175-e184

JO - Journal of Shoulder and Elbow Surgery

JF - Journal of Shoulder and Elbow Surgery

IS - 7

ER -

The role of an octacalcium phosphate in the re-formation of infraspinatus tendon insertion

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this