The role of correlated inhibitory cell firing

Ichiro Sakurai, Shigeru Kubota, Michio Niwano

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Maturation of γ-aminobutyric acid (GABA) function within the visual cortex is known to be involved in ocular dominance (OD) plasticity. However, only the circuits mediated by specific GABAA receptors can induce OD plasticity, implying a role of local GABA functions in this process. Here, we simulated the dynamics of synaptic population by spike-timing-dependent plasticity (STDP) to study the effects of local inhibitory functions on plasticity. Various forms of inhibitory pathways, such as horizontal, backward, and independent inhibition, were examined. We specifically investigated the activity-dependent competition between groups of inputs, which is required for the induction of experience-dependent plasticity. We show that the temporal correlation between excitatory and inhibitory inputs produced by horizontal inhibition facilitates competition. Conversely, the correlation between inhibitory inputs and postsynaptic activity through feedback inhibition suppresses competition. Our results may suggest that the distinct local GABA circuits can differently regulate the occurrence and level of visual plasticity by controlling the synaptic competition.

Original languageEnglish
Title of host publicationBrain and Health Informatics - International Conference, BHI 2013, Proceedings
Number of pages10
Publication statusPublished - 2013 Dec 1
EventInternational Conference on Brain and Health Informatics, BHI 2013 - Maebashi, Japan
Duration: 2013 Oct 292013 Oct 31

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume8211 LNAI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


OtherInternational Conference on Brain and Health Informatics, BHI 2013


  • Competition
  • Correlation
  • Inhibitory cell
  • STDP
  • Visual cortex

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)


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