The role of heavy-metal ATPases, HMAs, in zinc and cadmium transport in rice

Ryuichi Takahashi; Khurram Bashir; Yasuhiro Ishimaru; Naoko K. Nishizawa; Hiromi Nakanishi

doi:10.4161/psb.22454

The role of heavy-metal ATPases, HMAs, in zinc and cadmium transport in rice

Ryuichi Takahashi, Khurram Bashir, Yasuhiro Ishimaru, Naoko K. Nishizawa, Hiromi Nakanishi

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

149 Citations (Scopus)

Abstract

The P_1B-type heavy metal ATPases (HMAs) are diverse in terms of tissue distribution, subcellular localization, and metal specificity. Functional studies of HMAs have shown that these transporters can be divided into two subgroups based on their metal-substrate specificity: a copper (Cu)/silver (Ag) group and a zinc (Zn)/cobalt (Co)/cadmium (Cd)/lead (Pb) group. Studies on Arabidopsis thaliana and metal hyperaccumulator plants indicate that HMAs play an important role in the translocation or detoxification of Zn and Cd in plants. Rice possesses nine HMA genes, of which OsHMA1-OsHMA3 belong to the Zn/Co/ Cd/Pb subgroup. OsHMA2 plays an important role in root-toshoot translocation of Zn and Cd, and participates in Zn and Cd transport to developing seeds in rice. OsHMA3 transports Cd and plays a role in the sequestration of Cd into vacuoles in root cells. Modification of the expression of these genes might be an effective approach for reducing the Cd concentration in rice grains.

Original language	English
Pages (from-to)	1605-1607
Number of pages	3
Journal	Plant Signaling and Behavior
Volume	7
Issue number	12
DOIs	https://doi.org/10.4161/psb.22454
Publication status	Published - 2012

Keywords

Arabidopsis
Cadmium
HMA
Rice
Transporter
Zinc

ASJC Scopus subject areas

Plant Science

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10.4161/psb.22454

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title = "The role of heavy-metal ATPases, HMAs, in zinc and cadmium transport in rice",

abstract = "The P1B-type heavy metal ATPases (HMAs) are diverse in terms of tissue distribution, subcellular localization, and metal specificity. Functional studies of HMAs have shown that these transporters can be divided into two subgroups based on their metal-substrate specificity: a copper (Cu)/silver (Ag) group and a zinc (Zn)/cobalt (Co)/cadmium (Cd)/lead (Pb) group. Studies on Arabidopsis thaliana and metal hyperaccumulator plants indicate that HMAs play an important role in the translocation or detoxification of Zn and Cd in plants. Rice possesses nine HMA genes, of which OsHMA1-OsHMA3 belong to the Zn/Co/ Cd/Pb subgroup. OsHMA2 plays an important role in root-toshoot translocation of Zn and Cd, and participates in Zn and Cd transport to developing seeds in rice. OsHMA3 transports Cd and plays a role in the sequestration of Cd into vacuoles in root cells. Modification of the expression of these genes might be an effective approach for reducing the Cd concentration in rice grains.",

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author = "Ryuichi Takahashi and Khurram Bashir and Yasuhiro Ishimaru and Nishizawa, {Naoko K.} and Hiromi Nakanishi",

note = "Funding Information: This study was supported by the Program for Promotion of Basic Research Activities for Innovative Biosciences (PROBRAIN) and by a grant from the Ministry of Agriculture, Forestry and Fisheries of Japan (Genomics for Agricultural Innovation, GMB0001).",

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AU - Bashir, Khurram

AU - Ishimaru, Yasuhiro

AU - Nishizawa, Naoko K.

AU - Nakanishi, Hiromi

N1 - Funding Information: This study was supported by the Program for Promotion of Basic Research Activities for Innovative Biosciences (PROBRAIN) and by a grant from the Ministry of Agriculture, Forestry and Fisheries of Japan (Genomics for Agricultural Innovation, GMB0001).

PY - 2012

Y1 - 2012

N2 - The P1B-type heavy metal ATPases (HMAs) are diverse in terms of tissue distribution, subcellular localization, and metal specificity. Functional studies of HMAs have shown that these transporters can be divided into two subgroups based on their metal-substrate specificity: a copper (Cu)/silver (Ag) group and a zinc (Zn)/cobalt (Co)/cadmium (Cd)/lead (Pb) group. Studies on Arabidopsis thaliana and metal hyperaccumulator plants indicate that HMAs play an important role in the translocation or detoxification of Zn and Cd in plants. Rice possesses nine HMA genes, of which OsHMA1-OsHMA3 belong to the Zn/Co/ Cd/Pb subgroup. OsHMA2 plays an important role in root-toshoot translocation of Zn and Cd, and participates in Zn and Cd transport to developing seeds in rice. OsHMA3 transports Cd and plays a role in the sequestration of Cd into vacuoles in root cells. Modification of the expression of these genes might be an effective approach for reducing the Cd concentration in rice grains.

AB - The P1B-type heavy metal ATPases (HMAs) are diverse in terms of tissue distribution, subcellular localization, and metal specificity. Functional studies of HMAs have shown that these transporters can be divided into two subgroups based on their metal-substrate specificity: a copper (Cu)/silver (Ag) group and a zinc (Zn)/cobalt (Co)/cadmium (Cd)/lead (Pb) group. Studies on Arabidopsis thaliana and metal hyperaccumulator plants indicate that HMAs play an important role in the translocation or detoxification of Zn and Cd in plants. Rice possesses nine HMA genes, of which OsHMA1-OsHMA3 belong to the Zn/Co/ Cd/Pb subgroup. OsHMA2 plays an important role in root-toshoot translocation of Zn and Cd, and participates in Zn and Cd transport to developing seeds in rice. OsHMA3 transports Cd and plays a role in the sequestration of Cd into vacuoles in root cells. Modification of the expression of these genes might be an effective approach for reducing the Cd concentration in rice grains.

KW - Arabidopsis

KW - Cadmium

KW - HMA

KW - Rice

KW - Transporter

KW - Zinc

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The role of heavy-metal ATPases, HMAs, in zinc and cadmium transport in rice

Abstract

Keywords

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