TY - JOUR
T1 - The role of sex hormones in the kinetics of chondrocytes in the growth plate. A study in the rabbit
AU - Irie, T.
AU - Aizawa, T.
AU - Kokubun, S.
PY - 2005/9
Y1 - 2005/9
N2 - Sex hormones play important roles in the regulation of the proliferation, maturation and death of chondrocytes in the epiphyseal growth plate. We have investigated the effects of male castration on the cell kinetics of chondrocytes as defined by the numbers of proliferating and dying cells. The growth plates of normal rabbits and animals castrated at eight weeks of age were obtained at 10, 15, 20 and 25 weeks of age. Our study suggested that castration led to an increase in apoptosis and a decrease in the proliferation of chondrocytes in the growth plate. In addition, the number of chondrocytes in the castrated rabbits was less than that of normal animals of the same age.
AB - Sex hormones play important roles in the regulation of the proliferation, maturation and death of chondrocytes in the epiphyseal growth plate. We have investigated the effects of male castration on the cell kinetics of chondrocytes as defined by the numbers of proliferating and dying cells. The growth plates of normal rabbits and animals castrated at eight weeks of age were obtained at 10, 15, 20 and 25 weeks of age. Our study suggested that castration led to an increase in apoptosis and a decrease in the proliferation of chondrocytes in the growth plate. In addition, the number of chondrocytes in the castrated rabbits was less than that of normal animals of the same age.
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U2 - 10.1302/0301-620X.87B9.15583
DO - 10.1302/0301-620X.87B9.15583
M3 - Article
C2 - 16129759
AN - SCOPUS:25844456762
SN - 2049-4394
VL - 87
SP - 1278
EP - 1284
JO - Bone and Joint Journal
JF - Bone and Joint Journal
IS - 9
ER -