The role of the transcription factor pax6 in brain development and evolution: Evidence and hypothesis

Noriko Osumi; Takako Kikkawa

doi:10.1007/978-4-431-54496-8_3

The role of the transcription factor pax6 in brain development and evolution: Evidence and hypothesis

Noriko Osumi, Takako Kikkawa

MED - United Centers for Advanced Research and Translational Medicine (ART)

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

6 Citations (Scopus)

Abstract

During mammalian corticogenesis, the dorsal telencephalon is patterned through secreted molecules an transcription factors. Expression of the transcription factor Pax6 demarcates the dorsal telencephalon, thereby patterning the future cortical primordium. Pax6 is also crucial in neurogenesis in the developing cortex through its role in balancing proliferation and differentiation of neural progenitor cells (NPCs). In this chapter, we address the role of Pax6 and its downstream molecules in cortical development and evolution. We also note the possible involvement of Pax6 in the onset of neurodevelopmental diseases.

Original language	English
Title of host publication	Cortical Development
Subtitle of host publication	Neural Diversity and Neocortical Organization
Publisher	Springer Japan
Pages	43-62
Number of pages	20
ISBN (Electronic)	9784431544968
ISBN (Print)	9784431544951
DOIs	https://doi.org/10.1007/978-4-431-54496-8_3
Publication status	Published - 2013 Jan 1

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The role of the transcription factor pax6 in brain development and evolution: Evidence and hypothesis

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