During mammalian corticogenesis, the dorsal telencephalon is patterned through secreted molecules an transcription factors. Expression of the transcription factor Pax6 demarcates the dorsal telencephalon, thereby patterning the future cortical primordium. Pax6 is also crucial in neurogenesis in the developing cortex through its role in balancing proliferation and differentiation of neural progenitor cells (NPCs). In this chapter, we address the role of Pax6 and its downstream molecules in cortical development and evolution. We also note the possible involvement of Pax6 in the onset of neurodevelopmental diseases.
|Title of host publication||Cortical Development|
|Subtitle of host publication||Neural Diversity and Neocortical Organization|
|Number of pages||20|
|Publication status||Published - 2013 Jan 1|