The solid-phase parallel synthesis of β-strand mimetic templates via 1,3-dipolar cycloaddition with resin-bound vinylsulfone

Nobuhiro Fuchi; Takayuki Doi; Bolong Cao; Michael Kahn; Takashi Takahashi

doi:10.1055/s-2002-19783

The solid-phase parallel synthesis of β-strand mimetic templates via 1,3-dipolar cycloaddition with resin-bound vinylsulfone

Nobuhiro Fuchi, Takayuki Doi, Bolong Cao, Michael Kahn, Takashi Takahashi

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

A facile synthesis of a conformationally restricted β-strand mimetic library is described. Regioselective 1,3-dipolar cycloaddition with a resin-bound vinylsulfone provides a structurally diverse β-strand templated library. This library includes potent and selective inhibitors of serine proteases.

Original language	English
Pages (from-to)	285-289
Number of pages	5
Journal	Synlett
Issue number	2
DOIs	https://doi.org/10.1055/s-2002-19783
Publication status	Published - 2002

Keywords

1,3-dipolar cycloadditions
Combinatorial chemistry
Serine-protease inhibitor
Solid-phase synthesis
Vinylsulfones

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10.1055/s-2002-19783

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abstract = "A facile synthesis of a conformationally restricted β-strand mimetic library is described. Regioselective 1,3-dipolar cycloaddition with a resin-bound vinylsulfone provides a structurally diverse β-strand templated library. This library includes potent and selective inhibitors of serine proteases.",

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year = "2002",

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AU - Fuchi, Nobuhiro

AU - Doi, Takayuki

AU - Cao, Bolong

AU - Kahn, Michael

AU - Takahashi, Takashi

PY - 2002

Y1 - 2002

N2 - A facile synthesis of a conformationally restricted β-strand mimetic library is described. Regioselective 1,3-dipolar cycloaddition with a resin-bound vinylsulfone provides a structurally diverse β-strand templated library. This library includes potent and selective inhibitors of serine proteases.

AB - A facile synthesis of a conformationally restricted β-strand mimetic library is described. Regioselective 1,3-dipolar cycloaddition with a resin-bound vinylsulfone provides a structurally diverse β-strand templated library. This library includes potent and selective inhibitors of serine proteases.

KW - 1,3-dipolar cycloadditions

KW - Combinatorial chemistry

KW - Serine-protease inhibitor

KW - Solid-phase synthesis

KW - Vinylsulfones

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ER -

The solid-phase parallel synthesis of β-strand mimetic templates via 1,3-dipolar cycloaddition with resin-bound vinylsulfone

Abstract

Keywords

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