The study on β-lactamase of cefotaxime resistance escherichia coli

H. Matsuo, L. Ma, Y. Ishii, M. Kaku, K. Yamaguchi

Research output: Contribution to journalArticlepeer-review


Five strains of cefotaxime-resistant (≤ 128 μg/ml) Escherichia coli were isolated from hospitals in Nagasaki Prefecture. These E. coli strains showed resistance against 3rd generation cephems and aztreonam (64μg/ml), but these strains were sensitive against imipenem. The antibiotic activity of piperacillin alone to these E. coli strains were > 128 μg/ml, in contrast, MIC values of piperacillin combined with tazobactam as a β-lactamase inhibitor were 4-32 μg/ml. These resistance were carried by a conjugative plasmid encoding for β-lactamases. These results suggested that 5 strains of E. coli were shown resistance against β-lactams by producing class A β- lactamase.

Original languageEnglish
Pages (from-to)221-225
Number of pages5
JournalTherapeutic Research
Issue number7
Publication statusPublished - 1997
Externally publishedYes


  • Cefotaxamine-hydrolizing β-lactamase
  • Cefoxamine-resistant Escherichia coli
  • Extended-spectrum ̄- lactamase

ASJC Scopus subject areas

  • Medicine(all)


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