The synthesis of the CD ring of paclitaxel

Kazuoki Nakai; Shigeru Miyamoto; Daisuke Sasuga; Takayuki Doi; Takashi Takahashi

doi:10.1016/S0040-4039(01)01653-7

The synthesis of the CD ring of paclitaxel

Kazuoki Nakai, Shigeru Miyamoto, Daisuke Sasuga, Takayuki Doi, Takashi Takahashi

PHA - Molecular Pharmaceutical Science

Tokyo Institute of Technology

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

We have developed a practical synthetic route to the CD ring of paclitaxel. Unsaturated ester 8 was stereo- and regioselectively isomerized to 9. Stereoselective introduction of hydroxy groups and oxetane formation provided potential intermediate 4, which was coupled to an A ring moiety.

Original language	English
Pages (from-to)	7859-7862
Number of pages	4
Journal	Tetrahedron Letters
Volume	42
Issue number	44
DOIs	https://doi.org/10.1016/S0040-4039(01)01653-7
Publication status	Published - 2001 Oct 29

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title = "The synthesis of the CD ring of paclitaxel",

abstract = "We have developed a practical synthetic route to the CD ring of paclitaxel. Unsaturated ester 8 was stereo- and regioselectively isomerized to 9. Stereoselective introduction of hydroxy groups and oxetane formation provided potential intermediate 4, which was coupled to an A ring moiety.",

author = "Kazuoki Nakai and Shigeru Miyamoto and Daisuke Sasuga and Takayuki Doi and Takashi Takahashi",

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T1 - The synthesis of the CD ring of paclitaxel

AU - Nakai, Kazuoki

AU - Miyamoto, Shigeru

AU - Sasuga, Daisuke

AU - Doi, Takayuki

AU - Takahashi, Takashi

PY - 2001/10/29

Y1 - 2001/10/29

N2 - We have developed a practical synthetic route to the CD ring of paclitaxel. Unsaturated ester 8 was stereo- and regioselectively isomerized to 9. Stereoselective introduction of hydroxy groups and oxetane formation provided potential intermediate 4, which was coupled to an A ring moiety.

AB - We have developed a practical synthetic route to the CD ring of paclitaxel. Unsaturated ester 8 was stereo- and regioselectively isomerized to 9. Stereoselective introduction of hydroxy groups and oxetane formation provided potential intermediate 4, which was coupled to an A ring moiety.

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U2 - 10.1016/S0040-4039(01)01653-7

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SP - 7859

EP - 7862

JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

The synthesis of the CD ring of paclitaxel

Abstract

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