TY - JOUR
T1 - The Tohoku Medical Megabank Project
T2 - Design and mission
AU - the Tohoku Medical Megabank Project Study Group
AU - Kuriyama, Shinichi
AU - Yaegashi, Nobuo
AU - Nagami, Fuji
AU - Arai, Tomohiko
AU - Kawaguchi, Yoshio
AU - Osumi, Noriko
AU - Sakaida, Masaki
AU - Suzuki, Yoichi
AU - Nakayama, Keiko
AU - Hashizume, Hiroaki
AU - Tamiya, Gen
AU - Kawame, Hiroshi
AU - Suzuki, Kichiya
AU - Hozawa, Atsushi
AU - Nakaya, Naoki
AU - Kikuya, Masahiro
AU - Metoki, Hirohito
AU - Tsuji, Ichiro
AU - Fuse, Nobuo
AU - Kiyomoto, Hideyasu
AU - Sugawara, Junichi
AU - Tsuboi, Akito
AU - Egawa, Shinichi
AU - Ito, Kiyoshi
AU - Chida, Koichi
AU - Ishii, Tadashi
AU - Tomita, Hiroaki
AU - Taki, Yasuyuki
AU - Minegishi, Naoko
AU - Ishii, Naoto
AU - Yasuda, Jun
AU - Igarashi, Kazuhiko
AU - Shimizu, Ritsuko
AU - Nagasaki, Masao
AU - Koshiba, Seizo
AU - Kinoshita, Kengo
AU - Ogishima, Soichi
AU - Takai-Igarashi, Takako
AU - Tominaga, Teiji
AU - Tanabe, Osamu
AU - Ohuchi, Noriaki
AU - Shimosegawa, Toru
AU - Kure, Shigeo
AU - Tanaka, Hiroshi
AU - Ito, Sadayoshi
AU - Hitomi, Jiro
AU - Tanno, Kozo
AU - Nakamura, Motoyuki
AU - Ogasawara, Kuniaki
AU - Yamamoto, Masayuki
N1 - Publisher Copyright:
© 2016 Shinichi Kuriyama et al.
PY - 2016
Y1 - 2016
N2 - The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave rise to devastating damage on the Pacific coast of the Tohoku region. The Tohoku Medical Megabank Project (TMM), which is being conducted by Tohoku University Tohoku Medical Megabank Organization (ToMMo) and Iwate Medical University Iwate Tohoku Medical Megabank Organization (IMM), has been launched to realize creative reconstruction and to solve medical problems in the aftermath of this disaster. We started two prospective cohort studies in Miyagi and Iwate Prefectures: a population-based adult cohort study, the TMM Community-Based Cohort Study (TMM CommCohort Study), which will recruit 80 000 participants, and a birth and three-generation cohort study, the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study), which will recruit 70 000 participants, including fetuses and their parents, siblings, grandparents, and extended family members. The TMM CommCohort Study will recruit participants from 2013 to 2016 and follow them for at least 5 years. The TMM BirThree Cohort Study will recruit participants from 2013 to 2017 and follow them for at least 4 years. For children, the ToMMo Child Health Study, which adopted a cross-sectional design, was also started in November 2012 in Miyagi Prefecture. An integrated biobank will be constructed based on the two prospective cohort studies, and ToMMo and IMM will investigate the chronic medical impacts of the GEJE. The integrated biobank of TMM consists of health and clinical information, biospecimens, and genome and omics data. The biobank aims to establish a firm basis for personalized healthcare and medicine, mainly for diseases aggravated by the GEJE in the two prefectures. Biospecimens and related information in the biobank will be distributed to the research community. TMM itself will also undertake genomic and omics research. The aims of the genomic studies are: 1) to construct an integrated biobank; 2) to return genomic research results to the participants of the cohort studies, which will lead to the implementation of personalized healthcare and medicine in the affected areas in the near future; and 3) to contribute the development of personalized healthcare and medicine worldwide. Through the activities of TMM, we will clarify how to approach prolonged healthcare problems in areas damaged by large-scale disasters and how useful genomic information is for disease prevention.
AB - The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave rise to devastating damage on the Pacific coast of the Tohoku region. The Tohoku Medical Megabank Project (TMM), which is being conducted by Tohoku University Tohoku Medical Megabank Organization (ToMMo) and Iwate Medical University Iwate Tohoku Medical Megabank Organization (IMM), has been launched to realize creative reconstruction and to solve medical problems in the aftermath of this disaster. We started two prospective cohort studies in Miyagi and Iwate Prefectures: a population-based adult cohort study, the TMM Community-Based Cohort Study (TMM CommCohort Study), which will recruit 80 000 participants, and a birth and three-generation cohort study, the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study), which will recruit 70 000 participants, including fetuses and their parents, siblings, grandparents, and extended family members. The TMM CommCohort Study will recruit participants from 2013 to 2016 and follow them for at least 5 years. The TMM BirThree Cohort Study will recruit participants from 2013 to 2017 and follow them for at least 4 years. For children, the ToMMo Child Health Study, which adopted a cross-sectional design, was also started in November 2012 in Miyagi Prefecture. An integrated biobank will be constructed based on the two prospective cohort studies, and ToMMo and IMM will investigate the chronic medical impacts of the GEJE. The integrated biobank of TMM consists of health and clinical information, biospecimens, and genome and omics data. The biobank aims to establish a firm basis for personalized healthcare and medicine, mainly for diseases aggravated by the GEJE in the two prefectures. Biospecimens and related information in the biobank will be distributed to the research community. TMM itself will also undertake genomic and omics research. The aims of the genomic studies are: 1) to construct an integrated biobank; 2) to return genomic research results to the participants of the cohort studies, which will lead to the implementation of personalized healthcare and medicine in the affected areas in the near future; and 3) to contribute the development of personalized healthcare and medicine worldwide. Through the activities of TMM, we will clarify how to approach prolonged healthcare problems in areas damaged by large-scale disasters and how useful genomic information is for disease prevention.
KW - Biobank
KW - Cohort study
KW - Genomic research
KW - The Great East Japan Earthquake
KW - Tohoku Medical Megabank Project
UR - http://www.scopus.com/inward/record.url?scp=84991070369&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84991070369&partnerID=8YFLogxK
U2 - 10.2188/jea.JE20150268
DO - 10.2188/jea.JE20150268
M3 - Article
C2 - 27374138
AN - SCOPUS:84991070369
SN - 0917-5040
VL - 26
SP - 493
EP - 511
JO - Journal of Epidemiology
JF - Journal of Epidemiology
IS - 9
ER -