Abstract
A number of endogenous regulators of angiogenesis have been found in the body. We isolated vasohibin-1 (VASH1) as a negative feedback regulator of angiogenesis produced by endothelial cells, and then VASH2 as a homologue of VASH1. We further explored that VASH1 is expressed in endothelial cells to terminate angiogenesis, whereas VASH2 is expressed in non-endothelial cells in the sprouting front to promote angiogenesis. This chapter will focus on this vasohibin family members, novel regulators of angiogenesis.
| Original language | English |
|---|---|
| Title of host publication | Angiogenesis and Vascularisation |
| Subtitle of host publication | Cellular and Molecular Mechanisms in Health and Diseases |
| Publisher | Springer-Verlag Wien |
| Pages | 261-267 |
| Number of pages | 7 |
| ISBN (Electronic) | 9783709114285 |
| ISBN (Print) | 3709114276, 9783709114278 |
| DOIs | |
| Publication status | Published - 2013 Dec 1 |
Keywords
- Angiogenesis inhibitors
- Cancer
- Tumor angiogenesis
- Vasohibin-1
- Vasohibin-2
- VEGF
