A number of endogenous regulators of angiogenesis have been found in the body. We isolated vasohibin-1 (VASH1) as a negative feedback regulator of angiogenesis produced by endothelial cells, and then VASH2 as a homologue of VASH1. We further explored that VASH1 is expressed in endothelial cells to terminate angiogenesis, whereas VASH2 is expressed in non-endothelial cells in the sprouting front to promote angiogenesis. This chapter will focus on this vasohibin family members, novel regulators of angiogenesis.
|Title of host publication||Angiogenesis and Vascularisation|
|Subtitle of host publication||Cellular and Molecular Mechanisms in Health and Diseases|
|Number of pages||7|
|ISBN (Print)||3709114276, 9783709114278|
|Publication status||Published - 2013 Dec 1|
- Angiogenesis inhibitors
- Tumor angiogenesis