Thiophene-Based Organic D–π–A Dyes as Potent Sensitizers for Photodynamic Therapy

Shinichiro Fuse, Miori Takizawa, Keisuke Matsumura, Shinichi Sato, Shigetoshi Okazaki, Hiroyuki Nakamura

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


In this study, synthetically readily accessible, thiophene-based organic D–π–A sensitizers exerted high phototoxicity and are valuable as sensitizer templates for use in photodynamic therapy (PDT). Evaluation of the antitumor activity of our previously synthesized D–π–A sensitizers under photoirradiation revealed their potent phototoxicity. The structural requirements of the D–π–A sensitizer for phototoxicity were elucidated with the rapid synthesis of structurally simplified analogues and evaluation of their antitumor activity under photoirradiation. Our developed sensitizers mainly accumulated in mitochondria and damaged cancer cells through both Type I and Type II mechanisms. The developed new template could be useful in the future development of sensitizers that could fulfil the requirements for PDT.

Original languageEnglish
Pages (from-to)5170-5177
Number of pages8
JournalEuropean Journal of Organic Chemistry
Issue number34
Publication statusPublished - 2017 Sept 15
Externally publishedYes


  • Antitumor agents
  • Cross-coupling
  • Dyes/Pigments
  • Sensitizers
  • Singlet oxygen

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry


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