Three-dimensional visualization of a human chromosome using coherent X-ray diffraction

Yoshinori Nishino, Yukio Takahashi, Naoko Imamoto, Tetsuya Ishikawa, Kazuhiro Maeshima

Research output: Contribution to journalArticlepeer-review

250 Citations (Scopus)


Coherent x-ray diffraction microscopy is a lensless phase-contrast imaging technique with high image contrast. Although electron tomography allows intensive study of the three-dimensional structure of cellular organelles, it has inherent difficulty with thick objects. X rays have the unique benefit of allowing noninvasive analysis of thicker objects and high spatial resolution. We observed an unstained human chromosome using coherent x-ray diffraction. The reconstructed images in two or three dimensions show an axial structure, which has not been observed under unstained conditions.

Original languageEnglish
Article number018101
JournalPhysical Review Letters
Issue number1
Publication statusPublished - 2009 Jan 5


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