Three novel single nucleotide polymorphisms (SNPs) of CYP2S1 gene in Japanese individuals.

Yoshiyuki Hanzawa; Takamitsu Sasaki; Masahiro Hiratsuka; Masaaki Ishikawa; Michinao Mizugaki

doi:10.2133/dmpk.22.136

Three novel single nucleotide polymorphisms (SNPs) of CYP2S1 gene in Japanese individuals.

Yoshiyuki Hanzawa, Takamitsu Sasaki, Masahiro Hiratsuka, Masaaki Ishikawa, Michinao Mizugaki

PHA - Pharmacy

Tohoku Medical and Pharmaceutical University

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We analyzed all nine exons and exon-intron junctions of the CYP2S1 gene in 200 Japanese individuals and identified the following three novel single nucleotide polymorphisms (SNPs): 4612G>A (Glu147Glu) in exon 3, 5478C>T (Leu230Leu) and 5479T>G (Leu230Arg, CYP2S1*5A) in exon 5. The allele frequencies were 0.013 for 4612G>A, 0.058 for 5478C>T, and 0.003 for 5479T>G. In addition, a known SNP 1324C>G (Pro74Pro) was detected at a frequency of 0.300.

Original language	English
Pages (from-to)	136-140
Number of pages	5
Journal	Drug Metabolism and Pharmacokinetics
Volume	22
Issue number	2
DOIs	https://doi.org/10.2133/dmpk.22.136
Publication status	Published - 2007 Apr

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title = "Three novel single nucleotide polymorphisms (SNPs) of CYP2S1 gene in Japanese individuals.",

abstract = "We analyzed all nine exons and exon-intron junctions of the CYP2S1 gene in 200 Japanese individuals and identified the following three novel single nucleotide polymorphisms (SNPs): 4612G>A (Glu147Glu) in exon 3, 5478C>T (Leu230Leu) and 5479T>G (Leu230Arg, CYP2S1*5A) in exon 5. The allele frequencies were 0.013 for 4612G>A, 0.058 for 5478C>T, and 0.003 for 5479T>G. In addition, a known SNP 1324C>G (Pro74Pro) was detected at a frequency of 0.300.",

author = "Yoshiyuki Hanzawa and Takamitsu Sasaki and Masahiro Hiratsuka and Masaaki Ishikawa and Michinao Mizugaki",

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T1 - Three novel single nucleotide polymorphisms (SNPs) of CYP2S1 gene in Japanese individuals.

AU - Hanzawa, Yoshiyuki

AU - Sasaki, Takamitsu

AU - Hiratsuka, Masahiro

AU - Ishikawa, Masaaki

AU - Mizugaki, Michinao

PY - 2007/4

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N2 - We analyzed all nine exons and exon-intron junctions of the CYP2S1 gene in 200 Japanese individuals and identified the following three novel single nucleotide polymorphisms (SNPs): 4612G>A (Glu147Glu) in exon 3, 5478C>T (Leu230Leu) and 5479T>G (Leu230Arg, CYP2S1*5A) in exon 5. The allele frequencies were 0.013 for 4612G>A, 0.058 for 5478C>T, and 0.003 for 5479T>G. In addition, a known SNP 1324C>G (Pro74Pro) was detected at a frequency of 0.300.

AB - We analyzed all nine exons and exon-intron junctions of the CYP2S1 gene in 200 Japanese individuals and identified the following three novel single nucleotide polymorphisms (SNPs): 4612G>A (Glu147Glu) in exon 3, 5478C>T (Leu230Leu) and 5479T>G (Leu230Arg, CYP2S1*5A) in exon 5. The allele frequencies were 0.013 for 4612G>A, 0.058 for 5478C>T, and 0.003 for 5479T>G. In addition, a known SNP 1324C>G (Pro74Pro) was detected at a frequency of 0.300.

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Three novel single nucleotide polymorphisms (SNPs) of CYP2S1 gene in Japanese individuals.

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