Broadband wireless packet access will be the core technology of the next generation mobile communication systems. For very high-speed and high-quality packet transmissions in a limited bandwidth, the joint use of multipleinput multiple-output (MIMO) multiplexing and hybrid ARQ (HARQ) is an effective method. However, if single-carrier (SC) transmission is used, the transmission performance significantly degrades due to a large inter-symbol interference (ISI) resulting from a severe frequency-selective fading. In this paper, we propose an iterative frequency-domain successive interference cancellation (SIC) with two dimensional (2D) MMSE-FDE. At each iteration stage, the successive signal detection/cancellation is performed according to the descending order of the signal reliability. However, since the interference from the other transmit antennas can be only partially cancelled by performing SIC, the residual interference is present at the output of SIC. In this paper, we propose to update the 2D MMSE-FDE weights at each signal detection in order to suppress simultaneously the ISI and the interference from other antennas while obtaining antenna and frequency diversity gain. However, since a single use of SIC with 2D MMSE-FDE is insufficient, it is repeated a sufficient number of times. The bit error rate (BER) and HARQ throughput performance in a frequency-selective Rayleigh fading channel are evaluated by computer simulation.