TY - JOUR
T1 - Thyroid hormone transporters
T2 - Recent advances
AU - Abe, Takaaki
AU - Suzuki, Takehiro
AU - Unno, Michiaki
AU - Tokui, Taro
AU - Ito, Sadayoshi
PY - 2002/7
Y1 - 2002/7
N2 - Thyroid hormones, being hydrophobic, were thought to enter target cell membranes by passive diffusion. However, recent studies have documented the existence of numerous organic anion transport systems, about half of which also transport thyroid hormones into (and possibly out of) a variety of target cells. Several of the genes encoding thyroid hormone transporters have been characterized by means of molecular approaches. Here, we discuss the classification of thyroid hormone transporters, with emphasis on how they are influenced by their ionic milieu and what their symported organic anions are.
AB - Thyroid hormones, being hydrophobic, were thought to enter target cell membranes by passive diffusion. However, recent studies have documented the existence of numerous organic anion transport systems, about half of which also transport thyroid hormones into (and possibly out of) a variety of target cells. Several of the genes encoding thyroid hormone transporters have been characterized by means of molecular approaches. Here, we discuss the classification of thyroid hormone transporters, with emphasis on how they are influenced by their ionic milieu and what their symported organic anions are.
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U2 - 10.1016/S1043-2760(02)00599-4
DO - 10.1016/S1043-2760(02)00599-4
M3 - Review article
C2 - 12185668
AN - SCOPUS:0036636849
SN - 1043-2760
VL - 13
SP - 215
EP - 220
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 5
ER -
